RT Journal Article
ID 6c50c59429a731b4
A1 Ling, Harrod H. 
A1 Mendoza-Viveros, Lucia 
A1 Mehta, Neel 
A1 Cheng, Hai-Ying M. 
T1 Raf Kinase Inhibitory Protein (RKIP): Functional Pleiotropy in the Mammalian Brain
JF Critical Reviews™ in Oncogenesis
JO CRO
YR 2014
FD 2014-11-24
VO 19
IS 6
SP 505
OP 516
K1 Alzheimer's disease
K1 cancer
K1 circadian rhythms
K1 HCNP
K1 long-term depression
K1 neural differentiation
K1 PEBP1
K1 RKIP
AB In 1984, a cytosolic protein was isolated from bovine brain and coined phosphatidylethanolamine binding protein (PEBP) to describe its phospholipid-binding potential. Its cellular function remained elusive for more than a decade until it was discovered that PEBP had the ability to suppress the Raf1-mitogen activated protein kinase (MAPK) pathway, earning it the new name of Raf1 kinase inhibitory protein (RKIP). This milestone discovery has paved the way for numerous studies that have now extended the reach of RKIP's function to other signaling cascades, within the context of various physiological and pathophysiological systems. This review will summarize our current knowledge of the neurophysiological roles of RKIP in the mammalian brain, including its function in the circadian clock and synaptic plasticity. It will also discuss evidence for an involvement of RKIP and its derived neuropeptide, hippocampal cholinergic neurostimulating peptide (HCNP), in neural development and differentiation. Implications in certain pathologies such as Alzheimer's disease and brain cancer will be highlighted. By chronicling the diverse functions of RKIP in the brain, we hope that this review will serve as a timely resource that ignites future studies on this versatile, multifaceted protein in the nervous system.
PB Begell House
LK https://www.dl.begellhouse.com/journals/439f422d0783386a,492698d1102624fd,6c50c59429a731b4.html