%0 Journal Article %A Brutkiewicz, Randy R. %A Lin, Yinling %A Cho, Sungyoo %A Hwang, Yu Kyeong %A Sriram, Venkataraman %A Roberts, Tonya J. %D 2003 %I Begell House %N 5-6 %P 18 %R 10.1615/CritRevImmunol.v23.i56.30 %T CD1d-Mediated Antigen Presentation to Natural Killer T (NKT) Cells %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,4d2c88460d45d8db,7848353c3f8c0b0f.html %V 23 %X CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise. %8 2003-11-30