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NUMERICAL MODELING OF THE MOTION OF PARTICLES IN A BLOOD VESSEL: IMPLICATIONS FOR TARGETED DRUG DELIVERY

DOI: 10.1615/ICHMT.2015.IntSympAdvComputHeatTransf.910
pages 1031-1037

Helena Vitoshkin
Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA

Hsiu-Yu Yu
Departments of Chemical and Biomolecular Engineering & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

David M. Eckmann
Departments of Chemical and Biomolecular Engineering & Bioengineering, University of Pennsylvania, Philadelphia, PA; Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA

Ravi Radhakrishnan
Departments of Chemical and Biomolecular Engineering & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

Portonovo S. Ayyaswamy
Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA

Sinopsis

In this paper, we describe a numerical model for the ab initio evaluation of particulateladen flow in a vessel. We consider the multiphase flow problem that simulates blood flow in a vessel in the context of drug delivery. The blood is considered non-Newtonian and the red blood cells are coarse grained by solid spheres in the model. By carefully matching the viscosities of real blood with that of the model fluid, we describe the rheology. The predicted flow profile shows excellent comparison with a Casson profile. This lends credibility to the numerical modeling. This study is useful for describing, in general, multiphase particulate laden flows.

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