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EVALUATION OF MYOCARDIAL PERFUSION BY CONTRAST ECHOCARDIOGRAPHY

Samuel Sideman
Departments of Chemical and Biomedical Engineering The Julius Silver Institute of Biomedical Engineering Technion-Israel Institute of Technology, Haifa 32000, Israel

Shimon Reisner
Dept. of Cardiology, Rambam Medical Center, Haifa, Israel

Walter Markiewicz
Dept. of Cardiology, Rambam Medical Center, Haifa, Israel

Diana Rinkiewich
Dept. of Cardiology, Rambam Medical Center, Haifa, Israel

Rafael Beyar
The Julius Silver Institute, Department of Biomedical Engineering, The Heart System Research Center, Technion-Israel Institute of Technology, Haifa, Israel

Sinopsis

Competent invasive therapeutic methods have been introduced into clinical cardiology in recent years [1], and new imaging procedures have been developed for on-line evaluation of the results of these interventions. These include intravascular ultrasound and Doppler, transesophageal echocardiography and new methods for evaluating myocardial viability and perfusion.
DeMaria [2] noticed, in 1980, myocardial contrast after the injection of microbubbles into a coronary artery in an animal model. Meltzer [3] explained the mechanism of the contrast effect; microbubbles of air inhibit some acoustic properties, compared to the surrounding tissue, and cause a scatter of ultrasound waves resulting in an increased contrast effect. In view of the simplicity of contrast injection, the excellent resolution, and the wide availability of ultrasound machines, the advantage of Myocardial Contrast Echocardiography (MCE) over other potential methods for myocardial perfusion imaging is quite apparent.

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