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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Antitumor Potential of Thevetia peruviana on Ehrlich's Ascites Carcinoma−Bearing Mice

Volume 34, Numéro 2, 2015, pp. 105-113
DOI: 10.1615/JEnvironPatholToxicolOncol.2015012017
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RÉSUMÉ

Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12 ml, 2.88±0.23 ml, and 1.34±0.17 ml for the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. Nonviable cell counts were 4.44%±0.42%, 18.57%±3.07%, and 68.12%±5.32% in the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. METP-treated EAC cell-bearing mice had an increased life span (48.69% and 83.78%) compared to the EAC control group. Hematological and serum biochemical profiles were restored to normal levels in METP-treated mice compared to the EAC control group. METP significantly (P<0.001) decreased lipid peroxidation and recovered reduced glutathione, superoxide dismutase, and catalase toward normal levels compared to the EAC control group. In summary, METP exhibited remarkable antitumor activity in Swiss albino mice, which is plausibly attributable to its augmentation of endogenous antioxidant mechanisms.

CITÉ PAR
  1. Haldar Sagnik, Karmakar Indrajit, Chakraborty Mainak, Das Avratanu, Haldar Pallab Kanti, Preclinical assessment of Cascabela thevetia fruits on developmental toxicity and behavioral safety in zebrafish embryos, Oriental Pharmacy and Experimental Medicine, 15, 4, 2015. Crossref

  2. Bhadane Bhushan S., Patil Mohini P., Maheshwari Vijay L., Patil Ravindra H., Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review, Phytotherapy Research, 32, 7, 2018. Crossref

  3. Suárez Alírica Isabel, Chávez Katiuska, Appraisal of Medicinal Plants with Anticancer Properties in South America, in Anticancer plants: Properties and Application, 2018. Crossref

  4. Mendoza Dary, Cuaspud Olmedo, Arias Juan Pablo, Ruiz Orlando, Arias Mario, Effect of salicylic acid and methyl jasmonate in the production of phenolic compounds in plant cell suspension cultures of Thevetia peruviana, Biotechnology Reports, 19, 2018. Crossref

  5. Mendoza Dary, Arias Juan Pablo, Cuaspud Olmedo, Esturau-Escofet Nuria, Hernández-Espino Circe C., de San Miguel Eduardo Rodríguez, Arias Mario, 1H-NMR-based metabolomic of plant cell suspension cultures of Thevetia peruviana treated with salicylic acid and methyl jasmonate, Industrial Crops and Products, 135, 2019. Crossref

  6. Anand Uttpal, Nandy Samapika, Mundhra Avinash, Das Neela, Pandey Devendra Kumar, Dey Abhijit, A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms, Drug Resistance Updates, 51, 2020. Crossref

  7. Mendoza Dary, Arias Juan Pablo, Cuaspud Olmedo, Arias Mario, Phytochemical Screening of Callus and Cell Suspensions Cultures of Thevetia peruviana, Brazilian Archives of Biology and Technology, 63, 2020. Crossref

  8. Mendoza Dary, Arias Juan Pablo, Cuaspud Olmedo, Ruiz Orlando, Arias Mario, FT-NIR spectroscopy and RP-HPLC combined with multivariate analysis reveals differences in plant cell suspension cultures of Thevetia peruviana treated with salicylic acid and methyl jasmonate, Biotechnology Reports, 27, 2020. Crossref

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