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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity

Volume 29, Numéro 3, 2010, pp. 185-197
DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i3.30
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RÉSUMÉ

This study investigated the antioxidant effects of pecan nut (Carya illinoensis) shell aqueous extract (AE) on toxicity induced by cyclophosphamide (CP) in the heart, kidney, liver, bladder, plasma and erythrocytes of rats. Rats were treated with water or pecan shell AE (5%) ad libitum, replacing drinking water for 37 days up to the end of the experiment. On day 30, half of each group received a single administration of vehicle or CP 200 mg/kg-ip. After 7 days, the organs were removed. Rats treated with CP showed an increase in lipid peroxidation (LP) and decrease in reduced glutathione (GSH) levels in all structures. Catalase (CAT) activity was increased in the heart and decreased in liver and kidney. Besides, CP treatment decreased plasmatic vitamin C (VIT C) levels and induced bladder macroscopical and microscopical damages. In contrast, co-treatment with pecan shell AE prevented the LP development and the GSH depletion in all structures, except in the heart and plasma, respectively. CAT activity in the heart and liver as well as the plasmatic VIT C levels remained unchanged. Finally, AE prevented CP-induced bladder injury. These findings revealed the protective role of pecan shell AE in CP-induced multiple organ toxicity.

CITÉ PAR
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  2. Porto Luiz Carlos Santos, da Silva Juliana, de Barros Falcão Ferraz Alexandre, Corrêa Dione Silva, dos Santos Marcela Silva, Porto Caroline Dalla Lana, Picada Jaqueline Nascimento, Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch], Food and Chemical Toxicology, 59, 2013. Crossref

  3. Trevizol Fabiola, Benvegnú Dalila M., Barcelos Raquel C.S., Pase Camila S., Segat Hecson J., Dias Verônica Tironi, Dolci Geisa S., Boufleur Nardeli, Reckziegel Patrícia, Bürger Marilise E., Comparative study between two animal models of extrapyramidal movement disorders: Prevention and reversion by pecan nut shell aqueous extract, Behavioural Brain Research, 221, 1, 2011. Crossref

  4. Reckziegel P., Boufleur N., Barcelos R.C.S., Benvegnú D.M., Pase C.S., Muller L.G., Teixeira A.M., Zanella R., Prado A.C.P., Fett R., Block J.M., Burger M.E., Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: Beneficial effects of pecan nut shells extract, a by-product of the nut industry, Ecotoxicology and Environmental Safety, 74, 6, 2011. Crossref

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  9. Hilbig Josiane, Policarpi Priscila de Britto, Grinevicius Valdelúcia Maria Alves de Souza, Mota Nádia Sandrine Ramos Santos, Toaldo Isabela Maia, Luiz Marilde Terezinha Bordignon, Pedrosa Rozangela Curi, Block Jane Mara, Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice, Journal of Ethnopharmacology, 211, 2018. Crossref

  10. Hilbig Josiane, Alves Victor Rodrigues, Müller Carmen Maria Olivera, Micke Gustavo Amadeu, Vitali Luciano, Pedrosa Rozangela Curi, Block Jane Mara, Ultrasonic-assisted extraction combined with sample preparation and analysis using LC-ESI-MS/MS allowed the identification of 24 new phenolic compounds in pecan nut shell [Carya illinoinensis (Wangenh) C. Koch] extracts, Food Research International, 106, 2018. Crossref

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  13. Amaral Alexandra Aparecida do, Schuster Geciele Caroline, Boschen Nayara Lais, Benvegnú Dalila Moter, Wyzykowski Jair, Pinto Rodrigues Paulo Rogério, Gallina André Lazarin, Antioxidant Evaluation of Extracts of Pecan NutShell ( Carya illinoensis ) in Soybean Biodiesel B100 , Global Challenges, 3, 11, 2019. Crossref

  14. Dorsaf Hallegue, Sabrine Moujahed, Houda Ben Lamine, Khémais Ben Rhouma, Mohsen Sakly, Olfa Tebourbi, Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism in rats, Toxicology Research, 9, 5, 2020. Crossref

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