Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity
RÉSUMÉ
This study investigated the antioxidant effects of pecan nut (Carya illinoensis) shell aqueous extract (AE) on toxicity induced by cyclophosphamide (CP) in the heart, kidney, liver, bladder, plasma and erythrocytes of rats. Rats were treated with water or pecan shell AE (5%) ad libitum, replacing drinking water for 37 days up to the end of the experiment. On day 30, half of each group received a single administration of vehicle or CP 200 mg/kg-ip. After 7 days, the organs were removed. Rats treated with CP showed an increase in lipid peroxidation (LP) and decrease in reduced glutathione (GSH) levels in all structures. Catalase (CAT) activity was increased in the heart and decreased in liver and kidney. Besides, CP treatment decreased plasmatic vitamin C (VIT C) levels and induced bladder macroscopical and microscopical damages. In contrast, co-treatment with pecan shell AE prevented the LP development and the GSH depletion in all structures, except in the heart and plasma, respectively. CAT activity in the heart and liver as well as the plasmatic VIT C levels remained unchanged. Finally, AE prevented CP-induced bladder injury. These findings revealed the protective role of pecan shell AE in CP-induced multiple organ toxicity.
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Müller Liz Girardi, Pase Camila Simonetti, Reckziegel Patrícia, Barcelos Raquel C.S., Boufleur Nardeli, Prado Ana Cristina P., Fett Roseane, Block Jane Mara, Pavanato Maria Amália, Bauermann Liliane F., da Rocha João Batista Teixeira, Burger Marilise Escobar, Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage, Experimental and Toxicologic Pathology, 65, 1-2, 2013. Crossref
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Porto Luiz Carlos Santos, da Silva Juliana, de Barros Falcão Ferraz Alexandre, Corrêa Dione Silva, dos Santos Marcela Silva, Porto Caroline Dalla Lana, Picada Jaqueline Nascimento, Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch], Food and Chemical Toxicology, 59, 2013. Crossref
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Trevizol Fabiola, Benvegnú Dalila M., Barcelos Raquel C.S., Pase Camila S., Segat Hecson J., Dias Verônica Tironi, Dolci Geisa S., Boufleur Nardeli, Reckziegel Patrícia, Bürger Marilise E., Comparative study between two animal models of extrapyramidal movement disorders: Prevention and reversion by pecan nut shell aqueous extract, Behavioural Brain Research, 221, 1, 2011. Crossref
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Reckziegel P., Boufleur N., Barcelos R.C.S., Benvegnú D.M., Pase C.S., Muller L.G., Teixeira A.M., Zanella R., Prado A.C.P., Fett R., Block J.M., Burger M.E., Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: Beneficial effects of pecan nut shells extract, a by-product of the nut industry, Ecotoxicology and Environmental Safety, 74, 6, 2011. Crossref
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Porto Luiz Carlos S., da Silva Juliana, Ferraz Alexandre B. F., Ethur Eduardo M., Porto Caroline D. L., Marroni Norma P., Picada Jaqueline N., The Antidiabetic and Antihypercholesterolemic Effects of an Aqueous Extract from Pecan Shells in Wistar Rats, Plant Foods for Human Nutrition, 70, 4, 2015. Crossref
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Chang Sui Kiat, Alasalvar Cesarettin, Bolling Bradley W., Shahidi Fereidoon, Nuts and their co-products: The impact of processing (roasting) on phenolics, bioavailability, and health benefits – A comprehensive review, Journal of Functional Foods, 26, 2016. Crossref
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Merwid-Ląd A, Trocha M, Chlebda E, Sozański T, Magdalan J, Ksiądzyna D, Kopacz M, Kuźniar A, Nowak D, Pieśniewska M, Fereniec-Gołębiewska L, Kwiatkowska J, Szeląg A, Effects of morin-5′-sulfonic acid sodium salt (NaMSA) on cyclophosphamide-induced changes in oxido-redox state in rat liver and kidney, Human & Experimental Toxicology, 31, 8, 2012. Crossref
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Gallegos-Infante Jose Alberto, Rocha-Guzman Nuria Elizabeth, Gonzalez-Laredo Ruben Francisco, Moreno-Jimenez Martha Rocio, Pecans (Carya illinoinensis ), in Fruit and Vegetable Phytochemicals, 2017. Crossref
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Hilbig Josiane, Policarpi Priscila de Britto, Grinevicius Valdelúcia Maria Alves de Souza, Mota Nádia Sandrine Ramos Santos, Toaldo Isabela Maia, Luiz Marilde Terezinha Bordignon, Pedrosa Rozangela Curi, Block Jane Mara, Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice, Journal of Ethnopharmacology, 211, 2018. Crossref
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Hilbig Josiane, Alves Victor Rodrigues, Müller Carmen Maria Olivera, Micke Gustavo Amadeu, Vitali Luciano, Pedrosa Rozangela Curi, Block Jane Mara, Ultrasonic-assisted extraction combined with sample preparation and analysis using LC-ESI-MS/MS allowed the identification of 24 new phenolic compounds in pecan nut shell [Carya illinoinensis (Wangenh) C. Koch] extracts, Food Research International, 106, 2018. Crossref
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Charles Denys J., Sources of Natural Antioxidants and Their Activities, in Antioxidant Properties of Spices, Herbs and Other Sources, 2012. Crossref
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Lim T. K., Carya illinoensis, in Edible Medicinal And Non Medicinal Plants, 2012. Crossref
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Amaral Alexandra Aparecida do, Schuster Geciele Caroline, Boschen Nayara Lais, Benvegnú Dalila Moter, Wyzykowski Jair, Pinto Rodrigues Paulo Rogério, Gallina André Lazarin, Antioxidant Evaluation of Extracts of Pecan NutShell ( Carya illinoensis ) in Soybean Biodiesel B100 , Global Challenges, 3, 11, 2019. Crossref
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Dorsaf Hallegue, Sabrine Moujahed, Houda Ben Lamine, Khémais Ben Rhouma, Mohsen Sakly, Olfa Tebourbi, Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism in rats, Toxicology Research, 9, 5, 2020. Crossref
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Dunford Nurhan Turgut, Gumus Zinar Pinar, Gur Canan Sevimli, Chemical Composition and Antioxidant Properties of Pecan Shell Water Extracts, Antioxidants, 11, 6, 2022. Crossref