Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats
RÉSUMÉ
Nickel (Ni)-induced oxidative damage is a serious problem that leads to reproductive system failure through testicular damage. The present investigation was carried out to determine the effect of troxerutin (Txn) on testicular toxicity induced by Ni in experimental rat testes. The oral administration of Txn (100 mg/kg body weight [bw]) showed a significant (p < 0.01) increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione, ascorbate, total sulphydryl groups, and testis−organ weight. Subsequently, the administration of Txn also significantly reduced the accumulation of Ni, lipid peroxidation products, and protein carbonyl levels in Txn-treated animals. Testicular protection in the experimental animals by Txn is further substantiated by a remarkable reduction of Ni, which was revealed through testicular tissue histopathology. These studies suggest that Txn could prevent oxidative damage and testicular toxicity induced by Ni in experimental animals.
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Owumi Solomon E., Olayiwola Yusuff O., Alao Gbenga E., Gbadegesin Michael A., Odunola Oyeronke A., Cadmium and nickel co‐exposure exacerbates genotoxicity and not oxido‐inflammatory stress in liver and kidney of rats: Protective role of omega‐3 fatty acid, Environmental Toxicology, 35, 2, 2020. Crossref
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Cavalcanti Bruno Coêlho, Neto João Batista de Andrade, Silva Antônio Adailson de Sousa, Barreto Francisco Stefânio, Ferreira José Roberto de Oliveira, Magalhães Hemerson Iury Ferreira, Silva Cecília Rocha da, Vieira Ícaro Gusmão Pinto, Ricardo Nágila Maria Pontes Silva, Nobre Júnior Hélio Vitoriano, Moraes Manoel Odorico, Chemopreventive effect of troxerutin against hydrogen peroxide-induced oxidative stress in human leukocytes through modulation of glutathione-dependent enzymes, Journal of Toxicology and Environmental Health, Part A, 84, 4, 2021. Crossref
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Ahmadi Zahra, Mohammadinejad Reza, Roomiani Sahar, Afshar Elham Ghasemipour, Ashrafizadeh Milad, Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View, Journal of Pharmacopuncture, 24, 1, 2021. Crossref
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Zamanian Mohammad, Bazmandegan Gholamreza, Sureda Antoni, Sobarzo-Sanchez Eduardo, Yousefi-Manesh Hasan, Shirooie Samira, The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review, Current Neuropharmacology, 19, 1, 2020. Crossref
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Ghadiri Afsaneh, Bavil Fariba Mirzaei, Hamidian Gholam Reza, Oghbaei Hajar, Oskuye Zohreh Zavvari, Ahmadi Mahdi, Keyhanmanesh Rana, Can troxerutin pretreatment prevent testicular complications in prepubertal diabetic male rats?, Endocrine Regulations, 54, 2, 2020. Crossref