Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Effect of Marine Mangrove Avicennia marina (Forssk.) Vierh Against Acetic Acid−Induced Ulcerative Colitis in Experimental Mice
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RÉSUMÉ
Ulcerative colitis and Crohn's disease are two conditions that have many features in common and are referred as inflammatory bowel disease (IBD). Patients with IBD are predisposed to colorectal cancer. This investigation evaluates the effect of marine mangrove Avicennia marina against acetic acid−induced colitis. The treatment of A marina extract significantly decreased the colonic lipid peroxides, glutathione peroxidase, and serum nitric oxide and significantly increased the colonic and erythrocyte superoxide dismutase and glutathione levels compared with colitis control. In addition, A marina extract significantly decreased the lesion score and wet colon weight compared with colitis control. Treatment with A marina extract reflects its therapeutic activity against UC by minimal damage of colonic epithelial cells compared with colitis control during histopathologic examination. These protective role of A marina extract against UC could be attributed to the presence of higher levels of decanoic acid, diethylhydroxylamine (DEHA), pentanoic acid, pyrrolidine, 4-chlorophenyl, thiazolidinones, and arabinopyranoside (flavonoid). These findings suggest that A marina extract could be useful as a potential (natural) therapeutic agent for IBD.
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V. Vinod Prabhu, C. Guruvayoorappan, Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits, International Immunopharmacology, 18, 1, 2014. Crossref
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Moura Fabiana Andréa, de Andrade Kívia Queiroz, dos Santos Juliana Célia Farias, Araújo Orlando Roberto Pimentel, Goulart Marília Oliveira Fonseca, Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?, Redox Biology, 6, 2015. Crossref
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Yeom Yiseul, Kim Yuri, The Sasa quelpaertensis Leaf Extract Inhibits the Dextran Sulfate Sodium-induced Mouse Colitis Through Modulation of Antioxidant Enzyme Expression, Journal of Cancer Prevention, 20, 2, 2015. Crossref
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Debnath Trishna, Kim Da, Lim Beong, Natural Products as a Source of Anti-Inflammatory Agents Associated with Inflammatory Bowel Disease, Molecules, 18, 6, 2013. Crossref
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Mohammadi Erfan, Qujeq Durdi, Taheri Hassan, Hajian-Tilaki Karimollah, Evaluation of Serum Trace Element Levels and Superoxide Dismutase Activity in Patients with Inflammatory Bowel Disease: Translating Basic Research into Clinical Application, Biological Trace Element Research, 177, 2, 2017. Crossref
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Tian Tian, Wang Ziling, Zhang Jinhua, Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies, Oxidative Medicine and Cellular Longevity, 2017, 2017. Crossref
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Gharahkhani Azadeh, Pourjam Ebrahim, Pedram Majid, Inácio Maria Lurdes, Occurrence of Neodolichodorus persiangulfus n. sp. (Nematoda: Dolichodoridae) in mangrove forests of southern Iran, Forest Pathology, 49, 6, 2019. Crossref