Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Chemically Induced Skin Carcinogenesis in Mice and Its Prevention by Aegle marmelos (an Indian Medicinal Plant) Fruit Extract
RÉSUMÉ
This study assessed the chemopreventive potential of the Aegle marmelos plant on mouse skin tumorigenesis initiated by 7,12-dimethylbenz(a)anthracene (DMBA) and promoted by croton oil. A significant reduction in tumor incidence, tumor burden, tumor multiplicity, and the cumulative number of papillomas, along with a significant increase in the average latent period, was recorded in mice treated orally with A. marmelos extract (AME) at peri - and post-initiation phases (i.e., 7 days before DMBA application and continued until the end of the experiment) of papillomagenesis as compared with the carcinogen-treated controls. Furthermore, a significant increase in catalase activity, reduced glutathione and total proteins, and a depleted level of lipid peroxidation were observed in liver and skin of AME-treated animals as compared with the carcinogen-treated controls. Thus, the oral administration of AME, at a dose of 50 mg/kg body wt per day per animal, was found to be significantly effective in reducing skin tumors against chemical carcinogenesis in mice.
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Karabulut Aysun Bay, Karadag Nese, Gurocak Simay, Kiran Tugba, Tuzcu Mehmet, Sahin Kazım, Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NFκ-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy, Food and Chemical Toxicology, 70, 2014. Crossref
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Baliga Manjeshwar Shrinath, Rao Suresh, Rao Pratima, Krishnaprasad , Hegde Sanath Kumar, Akbar Kandel Codi Jalaluddin, Abraham Soniya, George Thomas, Palatty Princy Louis, Use of Indian Indigenous Fruits in Cancer Prevention and Treatment, in Anticancer plants: Properties and Application, 2018. Crossref
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Manandhar Bikash, Paudel Keshav Raj, Sharma Biraj, Karki Rajendra, Phytochemical profile and pharmacological activity of Aegle marmelos Linn., Journal of Integrative Medicine, 16, 3, 2018. Crossref
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Akbar Shahid, Aegle marmelos (L.) Corrêa (Rutaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref
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Masoodi Khalid Z., Amin Insha, Mansoor Sheikh, Ahmed Nazeer, Altay Volkan, Ozturk Munir, Botanicals from the Himalayas with anticancer potential: an emphasis on the Kashmir Himalayas, in Biodiversity and Biomedicine, 2020. Crossref
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Prabhakar Pankaj, Pavankumar Giriyapura Srikantachar, Raghu Shamprasad Varija, Rao Suresh, Prasad Krishna, George Thomas, Baliga Manjeshwar Shrinath, Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies, Current Pharmaceutical Design, 28, 19, 2022. Crossref