Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Journal of Environmental Pathology, Toxicology and Oncology
Facteur d'impact: 1.625 Facteur d'impact sur 5 ans: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018026697
pages 231-240

Cytotoxic Effect of Spondias cytherea Fruit Extract in Murine Melanoma Model In Vivo and In Vitro

Feudjio Ndemanou Yolande
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India; Department of Biochemistry, University of Dschang, Cameroon
Bhattacharyya Sayantan
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Ghosh Paramita
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Sarkar Deblina
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
Mouokeu Raymond Simplice
Department of Industrial Fishing, University of Douala, Cameroon
Tume B. Christopher
Department of Biochemistry, University of Dschang, Cameroon
Murmu Nabendu
Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India

RÉSUMÉ

Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer–related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied. We thus set out to evaluate the effects of S. cytherea fruit extract (SpE) on the epithelial to mesenchymal transition in the mouse melanoma model. B16-F10 cells cultured in varying concentrations of SpE showed a dose-dependent reduction in the ability to form colonies, which then migrate to fill up the wounded area. SpE downregulated the expression of AKT/nuclear factor kappa B/cyclooxygenase-2 (Akt/NF-κB/COX-2) responsible for cell proliferation, and reduced CD133 expression. This led to in vivo tumor shrinkage at the dose of 450 mg/kg body weight (bw). Low-level expression of vimentin on mesenchymal cells and increased E-cadherin expression on epithelial cells were observed in treated cells. The number of vasculogenic mimicry tubes that formed also decreased significantly at 450 mg/kg bw. These results suggest that S. cytherea fruit can become a useful source for chemotherapeutic drugs in the future.

MOTS CLÉS: CD133, COX-2, vimentin

Articles with similar content:

A Comparison Study of the Anticancerous Activity and Mechanism of Ethanolic Extracts from Different Ganoderma lucidum (W.Curt.:Fr.) Lloyd Strains
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Yang Qing-Yao, Mi Ke, Feng Hui-Qing, Zhou Yue-Qing, Xiao-Tong Yang, Xu-Quan Li
Cytotoxic Activities of Fractions of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), and the Induction of Cell Cycle Arrest and Apoptosis in MGC-803 Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 6
Fei-Fei Wang, Wei Ma, Ning Li , Feng Liu, Chao Shi, Kai-Jin Wang
The Effect of Culture Liquid Ethyl Acetate Mycelium Extracts of Medicinal Mushrooms on the Viability of Human Pancreatic Cancer Cells
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 2
Solomon P. Wasser, Lital E. Sharvit, Fuad Fares
KLF4 in Ovarian Cancer
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 1-2
Lawrence M. Pfeffer, Baojin Wang, Ziyun Du, Junming Yue
Regulation of Epithelial Cell Proliferation, Differentiation, and Plasticity by Grainyhead-Like 2 During Oral Carcinogenesis
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 3-4
Mo K. Kang, Wei Chen, No-Hee Park