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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Targeting MAPK (p38, ERK, JNK) and inflammatory CK (GDF-15, GM-CSF) in UVB-Activated Human Skin Cells with Vitis vinifera Seed Extract

Volume 37, Numéro 3, 2018, pp. 261-272
DOI: 10.1615/JEnvironPatholToxicolOncol.2018027009
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RÉSUMÉ

Ultraviolet B radiation (UVB) activates mitogen-activated protein kinases (MAPK): p38, extracellular signal regulated (ERK), and c-Jun N-terminal (JNK) kinases in human skin cells. Human keratinocytes (KC) exposed to UVB secrete several cytokines (CK), among which the growth differentiation factor-15 (GDF-15) is augmented in inflammatory and aging processes and the granulocyte macrophage-colony stimulating factor (GM-CSF) is involved in cell proliferation, differentiation, and survival, and both CK have implications in skin carcinogenesis. We assessed p38, ERK, JNK, GDF-15, and GM-CSF in UVB-exposed skin cells and a red grape (Vitis vinifera) seed extract's (GSE) capacities to regulate these pathways in UVB-exposed KC. Two concentrations of the GSE extract were selected: GSE1 (37.5 μgEqGA/mL) and GSE2 (75 μgEqGA/mL) and a UVB dose (100 mJ/cm2) within the physiological range. Molecules were assessed with ELISA, semiquantitative results being confirmed by Western blot. UVB triggered the signaling molecules' phosphorylation and the concentrations of CK. All molecules but GM-CSF increased early, at 2 h, from UVB exposure while GM-CSF increased later (at 8 h). MAPK and GDF-15 were regulated by GSE1; GM-CSF, by the higher concentration, GSE2. The amplitude and kinetics of the responses were diverse according to time point, molecules, and the extract's concentration. GSE exerted beneficial effects on MAPK and CK triggered by UVB in human skin cells: reduction of phosphorylation of the assessed signaling molecules and anti-inflammatory effects. Targeting MAPK and specific inflammatory mediators such as GDF-15 and GM-CSF with GSE in UVB-induced skin cells represents a novel and a promising starting point for future photoprotection strategies.

CITÉ PAR
  1. Ma Ming, Zhang Cong, Xiang Xiao-han, Deng Xiao-qing, Dai Su-li, Wei Si-si, Zhang Xiang-mei, Zhao Lian-mei, Liu Yun-jiang, Shan Bao-En, p-Hydroxylcinnamaldehyde from cochinchinamomordica seed reverses resistance to TRAIL in human oesophageal squamous cell carcinoma via the activation of the p38 mitogen-activated protein kinase signalling pathway, Biomedicine & Pharmacotherapy, 121, 2020. Crossref

  2. Roh Eunmiri, Han Yaping, Reddy Kanamata, Zykova Tatyana A., Lee Mee Hyun, Yao Ke, Bai Ruihua, Curiel-Lewandrowski Clara, Dong Zigang, Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032, Oncogene, 39, 21, 2020. Crossref

  3. Mazini Loubna, Rochette Luc, Admou Brahim, Amal Said, Malka Gabriel, Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing, International Journal of Molecular Sciences, 21, 4, 2020. Crossref

  4. Shi Lei, Sun Guan, Zhu Haifeng, Demethoxycurcumin analogue DMC-BH inhibits orthotopic growth of glioma stem cells by targeting JNK/ERK signaling, Aging, 12, 14, 2020. Crossref

  5. Martin Maria E, Grao-Cruces Elena, Millan-Linares Maria C, Montserrat-de la Paz Sergio, Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry, Foods, 9, 10, 2020. Crossref

  6. Singh Davinder, Kumar Avinash, Bhatia Astha, Singh Hasandeep, Kukreja Sahiba, Singh Balbir, Arora Saroj, Arora Rohit, Role of Phytochemicals in Modulating Signaling Cascades in Cancer Cells, in Pharmacotherapeutic Botanicals for Cancer Chemoprevention, 2020. Crossref

  7. Ma Jing, Jiang Xinghao, Yarui An, Danli Jin, Xiaodie Yin, Zhang Jian, Xu Ajing, Ultraviolet light activates PMK-1/p38 MAPK signaling via MOM-4 and JKK-1 in Caenorhabditis elegans, Toxicology Research, 9, 4, 2020. Crossref

  8. Ye Xiaoshuang, Jiang Juanjuan, Yang Juan, Yan Wenyan, Jiang Luyue, Chen Yan, Specnuezhenide suppresses diabetes-induced bone loss by inhibiting RANKL-induced osteoclastogenesis, Acta Biochimica et Biophysica Sinica, 54, 8, 2022. Crossref

  9. Wang Yapeng, Wu Yongwei, Wang Peng, Luo Junhao, Rui Yongjun, Ping Zhang, Exploration of the Protective Mechanism of Bax Removal against Ischemia Reperfusion Injury of Skin Flap through the p38 Mitogen-Activated Protein Kinase Pathway, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref

  10. Teng Yan, Huang Youming, Danfeng Xu, Tao Xiaohua, Fan Yibin, The Role of Probiotics in Skin Photoaging and Related Mechanisms: A Review, Clinical, Cosmetic and Investigational Dermatology, Volume 15, 2022. Crossref

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