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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Tomentosin Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Inflammatory Response by Suppression of the NF-κB Pathway in a Mouse Model of Sepsis

Volume 39, Numéro 4, 2020, pp. 291-298
DOI: 10.1615/JEnvironPatholToxicolOncol.2020035116
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RÉSUMÉ

Acute lung injury (ALI) is a severe inflammatory disorder that causes respiratory failure. Cases of ALI are reported with increasing mortality rates each year. In this study, we investigated the anti-inflammatory role of tomentosin and its fundamental mechanisms against lipopolysaccharide (LPS)-induced ALI via the suppression of Toll-like receptor (TLR4)/nuclear factor-kappa beta (NF-κB) pathway in a mouse model of sepsis. ALI was induced to BALB/c mice through the administration of 10 μg of LPS concomitantly with tomentosin (20 and 25 mg/kg) treatment. Dexamethasone was used as a standard drug. Inflammatory cells were measured using a hemocytometer; myeloperoxidase (MPO) enzyme activity and pro-inflammatory cytokines were determined using commercial kits. The lung tissues of animals were examined histologically. The expression level of TLR4/NF-κB signaling molecules were analyzed by Western blotting. Tomentosin treatment decreased lung edema and reduced the levels of macrophages, lymphocytes, and neutrophils in the bronchoalveolar lavage fluid. Tomentosin also suppressed the status of pro-inflammatory markers and reduced the activation of iNOS, MPO, COX-2, and PGE2 in the lung. Tomentosin appreciably down-regulated the NF-κB/TLR4 signaling pathway in sepsis mice. Histological study also showed the protective effects of tomentosin. These findings show that tomentosin protects the LPS-induced ALI via suppression of TLR4/NF-κB signaling pathway in sepsis mice. Tomentosin could be a promising therapeutic agent to treat sepsis.

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CITÉ PAR
  1. Liu Xue-Hui, Wu Li-Mei, Wang Jia-Li, Dong Xian-Hui, Zhang Shun-Chi, Li Xue-Heng, Xu Hui, Liu Da-Bin, Li Zhi-hai, Liu Zhe-Ming, Wu Shao-Guo, Hu Yan-Wei, Long non-coding RNA RP11-490M8.1 inhibits lipopolysaccharide-induced pyroptosis of human umbilical vein endothelial cells via the TLR4/NF-κB pathway, Immunobiology, 226, 5, 2021. Crossref

  2. Fan Xiaodan, Zhou Chun, Huang Cheng, Zhang Junye, Asperuloside ameliorates lipopolysaccharide-induced primary human periodontal ligament cell injury by decreasing TLR4 expression and NF-κB activation, Archives of Oral Biology, 129, 2021. Crossref

  3. El Omari Nasreddine, El Menyiy Naoual, Zengin Gokhan, Goh Bey Hing, Gallo Monica, Montesano Domenico, Naviglio Daniele, Bouyahya Abdelhakim, Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms, Separations, 8, 11, 2021. Crossref

  4. Han Jing, Zhang Siwang, Jiang Baoping, Wang Jingwen, Ge Xiaojing, Wu Bingrong, Zhang Sen, Wang Dongsheng, Sesquiterpene lactones from Xanthium sibiricum Patrin alleviate asthma by modulating the Th1/Th2 balance in a murine model, Phytomedicine, 99, 2022. Crossref

  5. Tomita Kengo, Okawara Toa, Ohira Chiharu, Morimoto Ai, Aihara Ryota, Kurihara Takashi, Fukuyama Tomoki, An Acceptable Concentration (0.1 ppm) of Ozone Exposure Exacerbates Lung Injury in a Mouse Model, American Journal of Respiratory Cell and Molecular Biology, 65, 6, 2021. Crossref

  6. Lu Shenggui, Wu Xinmiao, Xin Shuai, Zhang Jing, Lin Hanying, Miao Yu, Li Yixin, Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis, Bioengineered, 13, 3, 2022. Crossref

  7. Fang Zhengyu, Fang Jie, Gao Chunxiao, Wu Yueguo, Yu Wenying, Imran Ali, Aurantiamide Acetate Ameliorates Lung Inflammation in Lipopolysaccharide-Induced Acute Lung Injury in Mice, BioMed Research International, 2022, 2022. Crossref

  8. Yang Hailing, Zhang Chunmei, Zhao Zhongyan, Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-κB signaling pathway, Transplant Immunology, 74, 2022. Crossref

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