Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis
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RÉSUMÉ
Because humans commonly consume chokeberry, especially as a nutritional supplement, it must be checked to determine whether its excessive ingestion can cause adverse effects, in particular, in the case of simultaneous exposure to some xenobiotics. From this point of view, we examined the impact of long-term cotreatment of rats with chokeberry juice and hepatic carcinogen N-nitrosodiethylamine (NDEA) on oxidative damages and neoplastic lesions in the liver of rats. Daily exposure to chokeberry juice in a concentration of 10 g/kg feed via diet for 13 wk led to an intensified hepatotoxic effect of NDEA (0.01% in drinking water for 13 wk), as evidenced by changes in histopathological architecture of liver tissue, increased lipid peroxidation, protein carbonyl formation, and DNA degradation. Moreover, we noticed an increase in relative liver weight and a decrease in body weight in this group in comparison to NDEA-alone treated animals. Chokeberry juice applied alone did not cause any adverse effects in rats. On the basis of these findings, it can be concluded that high doses and longterm administration of chokeberry juice may enhance tumor-promoting action of some chemical carcinogens.
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Sidor Andrzej, Drożdżyńska Agnieszka, Gramza-Michałowska Anna, Black chokeberry (Aronia melanocarpa) and its products as potential health-promoting factors - An overview, Trends in Food Science & Technology, 89, 2019. Crossref
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Kalemba-Drożdż Małgorzata, Cierniak Agnieszka, Cichoń Iwona, Wang Li-Shu, Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP, Journal of Berry Research, 10, 1, 2020. Crossref
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Rodrigues Keuri Eleutério, de Oliveira Fábio Rodrigues, Barbosa Benilson Ramos Cassunde, Paraense Ricardo S. Oliveira, Bannwart Cahy Manoel, Pinheiro Bruno Gonçalves, Botelho Anderson de Santana, Muto Nilton Akio, do Amarante Cristine Bastos, Hamoy Moises, Macchi Barbarella de Matos, Maia Cristiane do Socorro Ferraz, do Prado Alejandro Ferraz, do Nascimento José Luiz Martins, Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury, Food and Chemical Toxicology, 133, 2019. Crossref
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Witucki Łukasz, Kurpik Monika, Jakubowski Hieronim, Szulc Michał, Łukasz Mikołajczak Przemysław, Jodynis-Liebert Jadwiga, Kujawska Małgorzata, Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease, Nutrients, 14, 10, 2022. Crossref