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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Inositol Hexaphosphate Induces Apoptosis by Coordinative Modulation of P53, Bcl-2 and Sequential Activation of Caspases in 7,12 Dimeth-ylbenz [a] anthracene Exposed Mouse Epidermis

Volume 27, Numéro 3, 2008, pp. 209-217
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i3.50
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RÉSUMÉ

Inositol hexaphosphate (IP6) is a major constituent of most cereals, legumes, nuts, oil seeds, and soybean. Anticancer effects of IP6 have been demonstrated in different experimental models. Besides reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in restoring the normal phenotype. Exogenously administered IP6 is rapidly taken into the cells and dephosphorylated to lower-phosphate, inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Enhanced immunity and antioxidant properties could also contribute to tumor cell destruction. However, the molecular mechanisms underlying this anticancer action are not fully understood. The present study deals with the effect of topical application of IP6 on some of the selective and critical events of apoptosis in DMBA exposed mouse epidermis. IP6 showed an inhibition of DMBA-induced mutant (mt) p53 expression. Similarly, DMBA induced over expression of Bcl-2 was also reversed by topical treatment of IP6. In addition to the modulation of mt p53 and Bcl-2 expressions, IP6 brought the DMBA-inhibited activity of caspases back to the normal or induced it above the normal levels. The effects of IP6 appeared to be the function of its dose and the duration of its exposure. These results suggested that topically applied IP6 directly induces apoptotic machinery by modulating the expression of mt p53, Bcl-2, and caspase activity.

CITÉ PAR
  1. Panjamurthy Kuppusamy, Manoharan Shanmugam, Nirmal Madhavan Ramados, Vellaichamy Lakshmanan, Protective role of Withaferin-A on immunoexpression of p53 and bcl-2 in 7,12-dimethylbenz(a)anthracene-induced experimental oral carcinogenesis, Investigational New Drugs, 27, 5, 2009. Crossref

  2. Sahay Satya, Upadhyay Daya S., Gupta Krishna P., N-Ethyl-N-nitrosourea-induced transplacental lung tumor development and its control: molecular modulations for tumor susceptibility in a mouse model, Toxicology Research, 4, 1, 2015. Crossref

  3. de Lima Eliane May, Kanunfre Carla Cristine, de Andrade Lucas Ferrari, Granato Daniel, Rosso Neiva Deliberali, Cytotoxic effect of inositol hexaphosphate and its Ni(II) complex on human acute leukemia Jurkat T cells, Toxicology in Vitro, 29, 8, 2015. Crossref

  4. Baskaran Nagarethinam, Manoharan Shanmugam, Balakrishnan Subramanian, Pugalendhi Pachaiappan, Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague–Dawley rats, European Journal of Pharmacology, 637, 1-3, 2010. Crossref

  5. Porres Jesus M., Cheng Wen-Hsing, Legumes and Preventive Dermatology, in Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013. Crossref

  6. Brehm Maria A., Windhorst Sabine, New options of cancer treatment employing InsP6, Biochemical Pharmacology, 163, 2019. Crossref

  7. Eberhard Matthias, Föller Michael, Lang Florian, Effect of Phytic Acid on Suicidal Erythrocyte Death, Journal of Agricultural and Food Chemistry, 58, 3, 2010. Crossref

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