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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Gene Profiling of Normal Human Bronchial Epithelial Cells in Response to Asbestos and Benzo(a)pyrene diol epoxide (BPDE)

Volume 26, Numéro 4, 2007, pp. 281-294
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i4.50
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RÉSUMÉ

Asbestos and benzo(a)pyrene diol epoxide (BPDE) are pulmonary carcinogens with synergistic interaction in causing lung cancer. We used Affymetrix microarrays to study gene modulation in vitro using normal human bronchial epithelial cells exposed to chrysotile asbestos and/or BPDE for 4 or 24 h. Linear models were used to compare treated cells to controls at each time point to identify statistically significant up- or downregulation of genes. Profiles of genes regulated by chrysotile were dominated by cytokines, growth factors, and DNA damage. Profiles of genes with BPDE and chrysotile regulation were correlated with proliferation, DNA damage recognition and nucleotide-excision repair, cytokines, and apoptosis. Chemokines, growth-regulated oncogene-alpha (Gro-α, CXCL-1), and IL-8, were significantly increased, and these had previously been observed in bronchoalveolar lavage from asbestos workers or in animal models. Interestingly, the Hermansky-Pudlak gene, which is mutated in an autosomal recessive form of pulmonary fibrosis, was downregulated threefold by BPDE at 4 h. This is an interesting example of gene (Hermansky-Pudlak syndrome) and environment (BPDE) interaction. Transcription factors, including activating transcription factor 3 and Cbp/p300-interacting transactivator, were upregulated by chrysotile. Real Time PCR for IL-8, ATF-3, GADD45B, CXC Ligand 1, and CTGF compared to GAPDH validated microarray findings at 24 h. These in vitro findings in NHBE cells model environment-gene interaction for asbestos and BPDE, highlighting effects of inflammation, fibrosis, proliferation, and DNA damage recognition and repair.

CITÉ PAR
  1. Huang Sarah X. L., Jaurand Marie-Claude, Kamp David W., Whysner John, Hei Tom K., Role of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases, Journal of Toxicology and Environmental Health, Part B, 14, 1-4, 2011. Crossref

  2. Yauk Carole Lyn, Jackson Kelly, Malowany Morie, Williams Andrew, Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 722, 2, 2011. Crossref

  3. Hillegass Jedd M., Shukla Arti, MacPherson Maximilian B., Bond Jeffrey P., Steele Chad, Mossman Brooke T., Utilization of Gene Profiling and Proteomics to Determine Mineral Pathogenicity in a Human Mesothelial Cell Line (LP9/TERT-1), Journal of Toxicology and Environmental Health, Part A, 73, 5-6, 2010. Crossref

  4. Chen Wenshu, Xu Xiuling, Bai Lang, Padilla Mabel T., Gott Katherine M., Leng Shuguang, Tellez Carmen S., Wilder Julie A., Belinsky Steven A., Scott Bobby R., Lin Yong, Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen, Carcinogenesis, 33, 7, 2012. Crossref

  5. Dreij Kristian, Rhrissorrakrai Kahn, Gunsalus Kristin C., Geacintov Nicholas E., Scicchitano David A., Benzo[ a ]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway, Carcinogenesis, 31, 6, 2010. Crossref

  6. Lu Xiangyun, Shao Jimin, Li Hongjuan, Yu Yingnian, Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line, Genomics, 93, 4, 2009. Crossref

  7. Øvrevik J., Låg M., Holme J.A., Schwarze P.E., Refsnes M., Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution, Toxicology, 259, 1-2, 2009. Crossref

  8. Seo Yoo-Na, Lee Yong-Jin, Lee Mi-Young, Differential gene expression by chrysotile in human bronchial epithelial cells, Animal Cells and Systems, 16, 2, 2012. Crossref

  9. Bausinger J., Speit G., DNA repair capacity of cultured human lymphocytes exposed to mutagens measured by the comet assay and array expression analysis, Mutagenesis, 30, 6, 2015. Crossref

  10. Lu Xiangyun, Shao Jimin, Li Hongjuan, Yu Yingnian, Temporal gene expression changes induced by a low concentration of benzo[a]pyrene diol epoxide in a normal human cell line, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 684, 1-2, 2010. Crossref

  11. Rappolee Daniel A., Awonuga Awoniyi O., Puscheck Elizabeth E., Zhou Sichang, Xie Yufen, Benzopyrene and Experimental Stressors Cause Compensatory Differentiation in Placental Trophoblast Stem Cells, Systems Biology in Reproductive Medicine, 56, 2, 2010. Crossref

  12. Osgood Ross S., Upham Brad L., Bushel Pierre R., Velmurugan Kalpana, Xiong Ka-Na, Bauer Alison K., Secondhand Smoke-Prevalent Polycyclic Aromatic Hydrocarbon Binary Mixture-Induced Specific Mitogenic and Pro-inflammatory Cell Signaling Events in Lung Epithelial Cells, Toxicological Sciences, 157, 1, 2017. Crossref

  13. Zaccaria Kimberly J., McClure Peter R., Using Immunotoxicity Information to Improve Cancer Risk Assessment for Polycyclic Aromatic Hydrocarbon Mixtures, International Journal of Toxicology, 32, 4, 2013. Crossref

  14. HELMIG SIMONE, DOPP ELKE, WENZEL SIBYLLE, WALTER DIRK, SCHNEIDER JOACHIM, Induction of altered mRNA expression profiles caused by fibrous and granular dust, Molecular Medicine Reports, 9, 1, 2014. Crossref

  15. Wu Meiqiong, Liang Gang, Duan Huiling, Yang Xiaofeng, Qin Guohua, Sang Nan, Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p/ transforming growth factor β type II receptor axis, Chemosphere, 219, 2019. Crossref

  16. Uskoković Vuk, Batarni Samir Shariff, Schweicher Julien, King Andrew, Desai Tejal A., Effect of Calcium Phosphate Particle Shape and Size on Their Antibacterial and Osteogenic Activity in the Delivery of Antibiotics in Vitro, ACS Applied Materials & Interfaces, 5, 7, 2013. Crossref

  17. Liu Gang, Cheresh Paul, Kamp David W., Molecular Basis of Asbestos-Induced Lung Disease, Annual Review of Pathology: Mechanisms of Disease, 8, 1, 2013. Crossref

  18. Korbecki Jan, Maruszewska Agnieszka, Bosiacki Mateusz, Chlubek Dariusz, Baranowska-Bosiacka Irena, The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin, International Journal of Molecular Sciences, 24, 1, 2022. Crossref

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