Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway
RÉSUMÉ
Liver cancer is the fifth commonly occurring cancer worldwide with the annual death rate of 9.1%. Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis. Because the cancer is generally detected only in the later stages, it is often treated with therapies such as radiation, ablation, and chemotherapy, which produces serious side effects and has a low recovery rate. Therefore, researchers are now focused on herbal-based drugs with increased efficacy and with no side effects to treat cancer. One such drug is mangiferin, a xanthanoid possessing augmented antioxidant, anti-inflammatory, and antidiabetic properties. The present study investigated the anticarcinogenic property of mangiferin against DEN-induced hepatocellular carcinoma. Hepatocellular carcinoma was induced in healthy Sprague-Dawley rats by treating them with 0.01% diethylnitrosamine (DEN) in the drinking water for 12 weeks, followed by 50 mg of mangiferin for a period of 8 weeks. Biochemical, oxidative stress markers, antioxidant status, and tumor marker level in the DEN- and DEN + mangiferin-treated rats liver were assessed to detect the efficacy of mangiferin in inhibiting cancer induction. The anticarcinogenic property of mangiferin was confirmed by evaluating the apoptotic protein expression and histological analysis of liver tissue from DEN- and DEN + mangiferin-treated rats. Our results show that mangiferin possesess anticarcinogenic properties against DEN-induced hepatocellular carcinoma. We predict that further investigation will reveal mangiferin as a potent drug to treat liver cancer.
-
Huang Jing, Zheng Lili, Wang Fang, Su Yuan, Kong Hongfang, Xin Hong, Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia, Archives of Pharmacal Research, 43, 2, 2020. Crossref
-
Naraki Karim, Rezaee Ramin, Mashayekhi‐Sardoo Habibeh, Hayes A. Wallace, Karimi Gholamreza, Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals, Phytotherapy Research, 35, 2, 2021. Crossref
-
Li Shaoxun, Jin Shuanghong, Chen Weilai, Yu Jiake, Fang Peipei, Zhou Guangyao, Li Jie, Jin Lingxiang, Chen Yiping, Chen Ping, Pan Chenwei, Mangiferin alleviates endoplasmic reticulum stress in acute liver injury by regulating the miR-20a/miR-101a-Nrf2 axis, The Journal of Biochemistry, 168, 4, 2020. Crossref
-
Morozkina Svetlana N., Nhung Vu Thi Hong, Generalova Yuliya E., Snetkov Petr P., Uspenskaya Mayya V., Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction, Biomolecules, 11, 1, 2021. Crossref
-
Jangra Ashok, Arora Mandeep Kumar, Kisku Anglina, Sharma Sonal, The multifaceted role of mangiferin in health and diseases: a review, Advances in Traditional Medicine, 21, 4, 2021. Crossref
-
Li Tao, Yang Gang, Hao Qiwei, Zhang Xin, Zhang Xiong, Daphnetin Ameliorates the Expansion of Chemically Induced Hepatocellular Carcinoma via Reduction of Inflammation and Oxidative Stress, Journal of Oleo Science, 71, 4, 2022. Crossref
-
Prabhakar Pankaj, Pavankumar Giriyapura Srikantachar, Raghu Shamprasad Varija, Rao Suresh, Prasad Krishna, George Thomas, Baliga Manjeshwar Shrinath, Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies, Current Pharmaceutical Design, 28, 19, 2022. Crossref
-
Kamal Monica A., Mandour Yasmine M., Abd El-Aziz Mostafa K., Stein Ulrike, El Tayebi Hend M., Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges, Molecules, 27, 17, 2022. Crossref