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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Reproductive and Developmental Toxicity Evaluation of Desoris (LLL 3348) in Wistar Rats

Volume 28, Numéro 4, 2009, pp. 361-370
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i4.100
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RÉSUMÉ

Desoris (LLL 3348), a lyophilized aqueous extract prepared from the leaves of Argemone mexicana to treat chronic stable plaque-type psoriasis, was evaluated for reproductive (male and female fertility) and developmental toxicity in rats. Lrrp: Wistar rats were administered orally with LLL 3348 at dose levels of 0 (distilled water), 250, 500, and 1000 mg/kg b.wt, and the effects on reproductive parameters were assessed. Sperm parameters (motility, epididymal sperm concentration, testicular sperm head count, and sperm morphology), organ weight, and histology of the male reproductive system were evaluated in the male fertility study. Estrus cyclicity, corpora lutea, implantation sites, litter size at birth, fetal growth, development parameters up to weaning, and organ weight and histology of male and female reproductive systems were assessed in the female fertility study. There were no overt signs of toxicity noted in male and female reproduction parameters in rats up to 1000 mg/kg of LLL 3348 administration. There were no alterations in the male reproductive organ/system, sperm parameters, male and female fertility indices, embryonic development, and pre-wean developmental landmarks of pups. No gross and histological changes were observed in these studies. In a develop mental toxicity study, the test article was administered to pregnant females during gestation (5−19 days) and the fetuses were examined for external, visceral, and skeletal abnormalities. No toxic manifestation was revealed on caesarian section parameters, and no fetus anomalies/abnormalities were found. Therefore, it is concluded that LLL 3348 at the given dose did not produce any significant toxic effect in rats. The No Observed Adverse Effect Level (NOAEL) for male fertility, female fertility, and developmental toxicity studies was established as 1000 mg/kg in rats.

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  1. Sharma Ashutosh, Flores-Vallejo Rosario del Carmen, Cardoso-Taketa Alexandre, Villarreal María Luisa, Antibacterial activities of medicinal plants used in Mexican traditional medicine, Journal of Ethnopharmacology, 208, 2017. Crossref

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