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Journal of Environmental Pathology, Toxicology and Oncology
Facteur d'impact: 1.241 Facteur d'impact sur 5 ans: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i4.50
pages 303-309

Acute Toxicity Effects of Prunus avium Fruit Extract and Selection of Optimum Dose Against Radiation Exposure

Rashmi Sisodia
University of Rajasthan, Jaipur
K. V. Sharma
Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan 302055
Smita Singh
Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan; Biyani Girls College, Jaipur, India

RÉSUMÉ

The objective of the study was to evaluate the acute toxicity of different doses of the methanolic extract of the fruit pulp of Prunus avium (family Rosaceae), which is used ethnomedicinally for the treatment of various diseases, and to find out the optimal dose of Prunus avium extract against 10 Gy γ-radiation exposure. To test acute toxicity in mice, different doses of PAE (Prunus avium fruit extract) were given orally for 15 consecutive days, after which the animals were observed for another 15 days; the LD50/15 of the methanolic extract was calculated to be 4.947 gm/kg body weight (b.wt). In optimum dose selection against radiation exposure, oral administration of 450 mg/kg b.wt/d of PAE for 15 consecutive days before exposure to 10 Gy of γ-radiation was found to afford maximum protection in terms of body weight and survivability of the mice in comparison to other doses.