Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Journal of Environmental Pathology, Toxicology and Oncology
Facteur d'impact: 1.241 Facteur d'impact sur 5 ans: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i2.80
pages 163-175

Guilandina bonduc L. Possesses Antioxidant Activity and Precludes Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Toxicity and Tumor Promotion Response

Gurpreet Kaur
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi; Department of Medical Elementology & Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
Irshad A. Lone
Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
Mohammad Athar
Department of Medical Elementology & Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India
Sarwar M. Alam
Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India

RÉSUMÉ

Guilandina bonduc Linn. (Fabaceae), a prickly shrub that grows abundantly in tropical and subtropical regions of Southeast Asia, possesses an extensive medicinal value. The present communication reports ethanolic extract of G. bonduc fruit pods to possess potent antioxidant activity and significantly protect against Ferric Nitrilotriacetate (Fe-NTA)−induced renal oxi-dative stress, nephrotoxicity, and tumor promotion response. Intraperitoneal administration of Fe-NTA (9 mg Fe/Kg body weight) to Swiss albino mice depleted renal antioxidant armory (glutathione content and activities of antioxidant enzymes), and caused oxidative stress, induced inflammation (inducing the expression of inducible nitric oxide synthase and cyclooxygenase-2 and increasing the secretion of proinflammatory cytokines). It also induced hyperproliferation in kidney-enhancing ornithine decarboxylase (ODC) activity and [3H]-thymidine incorporation into DNA. Histopathological changes and levels of serum creatinine (SCr) and blood urea nitrogen (BUN) suggested Fe-NTA to afflict substantial damage to the kidney. Prophylactic treatment of mice with G. bonduc extract (100−200 mg /Kg body weight) for seven days not only restored renal antioxidant armory close to normal, but also significantly precluded Fe-NTA associated inflammation and hyperproliferation. Furthermore, pretreatment with extract markedly prevented renal oxidative damage and histopathological alterations, and restored the levels of renal damage markers close to control values. The data obtained in the present study indicate G. bonduc fruit pods to possess a potent antioxidant activity and avert chemically inflicted renal oxidative damage and tumor promotion response.


Articles with similar content:

Protective Effect of Curcumin Against Carbofuran-Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 1
Binitha P. Purushothaman, Ramadasan Kuttan
Heavy Metal−Induced Systemic Dysfunction Attenuated by Tannic Acid
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Pooja Sharma, Suhel Parvez, Heena Tabassum, Saima Khatoon, Dilruba Haque, Mohammad Ashafaq
Chemopreventive Efficacy of (+)-Catechin-Rich Aqueous Extract of Acacia catechu Willd. Heartwood against 7,12-Dimethylbenz[a]Anthracene-Induced Hepatocarcinoma in Balb/c Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Manu Sharma, Jitender Monga, Chetan Singh Chauhan
Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine–Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Abul Vafa, Rahat Ali, Sarwat Sultana, Aisha Siddiqi, Alpashree, Preeti Barnwal, Syed Kazim Hasan, Shekh Mohammad Afzal, Johirul Islam
MT-α-Glucan from the Fruit Body of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomyetes) Shows Protective Effects for Hypoglycemic Pancreatic β-Cells
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Hong Lei, Shuzhen Guo, Qin Wang, Hanju Sun, Juncheng Han, Wutong Wu, Minmin Zhang