Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Facilitated Delivery of ALA to Inaccessible Regions via Bioadhesive Patch Systems
RÉSUMÉ
5-Aminolevulinic acid (ALA) is now being increasingly used in photodynamic therapy (PDT) and photodiagnosis (PDD) of lesions of the oral cavity, esophagus, and female genital tract. Clearly, topically applied creams and solutions are not the most suitable drug delivery systems for such moist and irregularly shaped areas, where shear forces may be high. As a result, such areas of the body are currently relatively inaccessible to efficient topical delivery of ALA. The use of a bioadhesive patch for topical delivery of ALA to the lower female genital tract and now, for the first time, to the human lip, is described. Use of the patch, containing 38 mg ALA cm−2, allowed successful PDT of vulval intraepithelial neoplasia lesions and induced protoporphyrin IX production in Herpes simplex lesions of the lip.
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Harris Frederick, Pierpoint Lynne, Photodynamic therapy based on 5-aminolevulinic acid and its use as an antimicrobial Agent, Medicinal Research Reviews, 32, 6, 2012. Crossref
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Ascencio Manuel, Collinet Pierre, Farine M.O., Mordon Serge, Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy, Lasers in Surgery and Medicine, 40, 5, 2008. Crossref
-
Phoenix David A., Dennison Sarah R., Harris Frederick, Photodynamic Antimicrobial Chemotherapy, in Novel Antimicrobial Agents and Strategies, 2014. Crossref
-
Morton C.A., McKenna K.E., Rhodes L.E., Guidelines for topical photodynamic therapy: update, British Journal of Dermatology, 159, 6, 2008. Crossref
-
Ascencio Manuel, Estevez Juan Pablo, Delemer Marie, Farine Marie Odile, Collinet Pierre, Mordon Serge, Comparison of continuous and fractionated illumination during hexaminolaevulinate-photodynamic therapy, Photodiagnosis and Photodynamic Therapy, 5, 3, 2008. Crossref
-
Juzeniene Asta, Moan Johan, The history of PDT in Norway, Photodiagnosis and Photodynamic Therapy, 4, 2, 2007. Crossref
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Zawislak A., Donnelly R.F., McCluggage W.G., Price J.H., McClelland H.R., Woolfson A.D., Dobbs S., Maxwell P., McCarron P.A., Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid, Photodiagnosis and Photodynamic Therapy, 6, 1, 2009. Crossref
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Estevez Juan Pablo, Ascencio Manuel, Colin Pierre, Farine Marie Odile, Collinet Pierre, Mordon Serge, Continuous or fractionated photodynamic therapy? Comparison of three PDT schemes for ovarian peritoneal micrometastasis treatment in a rat model, Photodiagnosis and Photodynamic Therapy, 7, 4, 2010. Crossref
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Morrow Desmond I.J., McCarron Paul A., Woolfson A. David, Juzenas Petras, Juzeniene Asta, Iani Vladimir, Moan Johan, Donnelly Ryan F., Novel patch-based systems for the localised delivery of ALA-esters, Journal of Photochemistry and Photobiology B: Biology, 101, 1, 2010. Crossref
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Ascencio Manuel, Delemer Marie, Farine M.O., Jouve Eva, Collinet Pierre, Mordon Serge, Evaluation of ALA-PDT of ovarian cancer in the Fisher 344 rat tumor model, Photodiagnosis and Photodynamic Therapy, 4, 4, 2007. Crossref
-
Yavlovich Amichai, Smith Brandon, Gupta Kshitij, Blumenthal Robert, Puri Anu, Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications, Molecular Membrane Biology, 27, 7, 2010. Crossref
-
Newman J. Robert, Rosenthal Eben L., Optical Imaging of Primary Tumors, in Optical Imaging of Cancer, 2010. Crossref
-
Specific Therapeutic Agents, in British Association of Dermatologists' Management Guidelines, 2011. Crossref
-
Li Wei, Yamada Ichiro, Masumoto Kazuma, Ueda Yoshio, Hashimoto Kenji, Photodynamic therapy with intradermal administration of 5-aminolevulinic acid for port-wine stains, Journal of Dermatological Treatment, 21, 4, 2010. Crossref