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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Facilitated Delivery of ALA to Inaccessible Regions via Bioadhesive Patch Systems

Volume 25, Numéro 1-2, 2006, pp. 389-402
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.240
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RÉSUMÉ

5-Aminolevulinic acid (ALA) is now being increasingly used in photodynamic therapy (PDT) and photodiagnosis (PDD) of lesions of the oral cavity, esophagus, and female genital tract. Clearly, topically applied creams and solutions are not the most suitable drug delivery systems for such moist and irregularly shaped areas, where shear forces may be high. As a result, such areas of the body are currently relatively inaccessible to efficient topical delivery of ALA. The use of a bioadhesive patch for topical delivery of ALA to the lower female genital tract and now, for the first time, to the human lip, is described. Use of the patch, containing 38 mg ALA cm−2, allowed successful PDT of vulval intraepithelial neoplasia lesions and induced protoporphyrin IX production in Herpes simplex lesions of the lip.

CITÉ PAR
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