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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Spectroscopic Measurements of Photoinduced Processes in Human Skin after Topical Application of the Hexyl Ester of 5-Aminolevulinic Acid

Volume 25, Numéro 1-2, 2006, pp. 307-320
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.200
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RÉSUMÉ

Although 5-aminolevulinic acid, ALA, and its derivatives, have been widely studied and applied in clinical photodynamic therapy (PDT), there is still a lack of reliable and non-invasive methods and technologies to evaluate physiological parameters of relevance for the therapy, such as erythema, melanogenesis, and oxygen level. We have investigated the kinetics of these parameters in human skin in vivo during and after PDT with the hexyl ester of ALA, ALA-Hex. Furthermore, the depth of photosensitizer (protoporphyrin IX, PpIX) production after different application times was investigated. It was found that the depth increased with increasing application time of ALA-Hex. We also investigated the depth of PpIX before and after light exposure causing 50% photobleaching at 407 nm. The PpIX localized in superficial layers of the normal tissue was removed during the bleaching. Thus, after bleaching, the remaining PpIX was localized mainly in the deeper layers of normal tissue. We have applied fluorescence emission spectroscopy, fluorescence excitation spectroscopy, and reflectance spectroscopy in the study of the above-mentioned parameters. In conclusion, fluorescence excitation spectroscopy and reflectance spectroscopy are simple, useful, reliable, and noninvasive techniques in the evaluation of the processes taking place in human skin in vivo during and after PDT. Using these methods we were able to quantify melanogenesis, O2 level, erythema, vasoconstriction, and vasodilatation.

CITÉ PAR
  1. Togsverd-Bo Katrine, Idorn Luise W., Philipsen Peter A., Wulf Hans Christian, Haedersdal Merete, Protoporphyrin IX formation and photobleaching in different layers of normal human skin: Methyl- and hexylaminolevulinate and different light sources, Experimental Dermatology, 21, 10, 2012. Crossref

  2. Middelburg T.A., de Bruijn H.S., Tettero L., van der Ploeg van den Heuvel A., Neumann H.A.M., de Haas E.R.M., Robinson D.J., Topical hexylaminolevulinate and aminolevulinic acid photodynamic therapy: Complete arteriole vasoconstriction occurs frequently and depends on protoporphyrin IX concentration in vessel wall, Journal of Photochemistry and Photobiology B: Biology, 126, 2013. Crossref

  3. Juzeniene Asta, Nielsen Kristian Pagh, Zhao Lu, Ryzhikov Gennady A., Biryulina Marina S., Stamnes Jakob J., Stamnes Knut, Moan Johan, Changes in human skin after topical PDT with hexyl aminolevulinate, Photodiagnosis and Photodynamic Therapy, 5, 3, 2008. Crossref

  4. Juzeniene Asta, Juzenas Petras, Iani Vladimir, Moan Johan, Reflectance spectroscopy and fluorescein angiography applied to assess photodynamic response in healthy mouse skin treated with topical hexylaminolevulinate, Photodiagnosis and Photodynamic Therapy, 7, 4, 2010. Crossref

  5. Piffaretti Filippo M., Santhakumar Kanappan, Forte Eddy, van den Bergh Hubert E., Wagnières Georges A., Optical fiber-based setup for in vivo measurement of the delayed fluorescence lifetime of oxygen sensors, Journal of Biomedical Optics, 16, 3, 2011. Crossref

  6. Baglo Yan, Sousa Mirta M. L., Slupphaug Geir, Hagen Lars, Håvåg Sissel, Helander Linda, Zub Kamila A., Krokan Hans E., Gederaas Odrun A., Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways, Photochemical & Photobiological Sciences, 10, 7, 2011. Crossref

  7. Nielsen K.P., Zhao L., Ryzhikov G.A., Biryulina M.S., Sommersten E.R., Stamnes J.J., Stamnes K., Moan J., Retrieval of the physiological state of human skin from UV–Vis reflectance spectra – A feasibility study, Journal of Photochemistry and Photobiology B: Biology, 93, 1, 2008. Crossref

  8. Stamnes Knut, Stamnes Jakob J., Radiative Transfer in Coupled Systems, in Light Scattering Reviews, Vol. 6, 2012. Crossref

  9. Foged Camilla, Philipsen Peter Alshede, Wulf Hans Christian, Haedersdal Merete, Togsverd-Bo Katrine, Skin surface Protoporphyrin IX fluorescence is associated with epidermal but not dermal fluorescence intensities, Photodiagnosis and Photodynamic Therapy, 30, 2020. Crossref

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