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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Effects of Testosterone Propionate on Oxidative Stress and the Expression of Spleen Cytokine Genes in Endosulfan-Treated Mice

Volume 31, Numéro 1, 2012, pp. 17-26
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.30
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RÉSUMÉ

The purpose of this research was to investigate the effects of testosterone propionate on oxidative stress and cytokine gene expression in endosulfan-treated mice. The levels of endosulfan and testosterone propionate were 0 and 0 mg⋅kg−1⋅d−1 (control group), 0.8 and 0 mg⋅kg−1⋅d−1 (endosulfan-treated group), and 0.8 and 10 mg⋅kg−1⋅d−1 (experimental group), respectively. The results showed that total antioxidation capability (T-AOC) in the endosulfan-treated group was reduced significantly when compared with the control group, whereas the levels of malondialdehyde (MDA) and hydroxyl free radicals increased when compared with the control group. T-AOC levels in the experimental group were higher than that of the endosulfan-treated group, and the levels of MDA and hydroxyl free radicals decreased when compared with the endosulfan-treated group. The messenger RNA (mRNA) levels of interleukin (IL)-2 and IL-6 in the endosulfan-treated group were significantly higher than that of the control group. The mRNA levels of IL-6 in the experimental group were lower than that of the endosulfan-treated group, whereas the mRNA levels of IL-2 and interferon-γ had no significant difference between the 2 groups. The results suggest that testosterone propionate alleviates oxidative stress induced by endosulfan and at least partially reverses the changes of cytokine gene expression in mice. It is possible that androgens affect cytokine expression by alleviating oxidative stress induced by endosulfan.

CITÉ PAR
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  2. Luo Xue, Jia Shujie, Ma Qinlong, Zhong Min, Gao Peng, Yu Zhengping, Zhang Yanwen, Suppressive Effects of Subchronic Aluminum Overload on the Splenic Immune Function May Be Related to Oxidative Stress in Mice, Biological Trace Element Research, 157, 3, 2014. Crossref

  3. Tsai Meng-Chang, Huang Tiao-Lai, Thiobarbituric acid reactive substances (TBARS) is a state biomarker of oxidative stress in bipolar patients in a manic phase, Journal of Affective Disorders, 173, 2015. Crossref

  4. Wang Na, Xu Ying, Zhou Xian-Qing, Wu Yan-Hua, Li Sheng-Li, Qiao Xin, Li Yan-Bo, Sun Zhi-Wei, Protective effects of testosterone propionate on reproductive toxicity caused by Endosulfan in male mice, Environmental Toxicology, 31, 2, 2016. Crossref

  5. Tsai Meng-Chang, Huang Tiao-Lai, Brain-derived neurotrophic factor (BDNF) and oxidative stress in heroin-dependent male patients undergoing methadone maintenance treatment, Psychiatry Research, 249, 2017. Crossref

  6. Zhao Yan-Zhi, Jia Jing, Li Yan-Bo, Guo Cai-Xia, Zhou Xian-Qing, Sun Zhi-Wei, Effects of endosulfan on the immune function of erythrocytes, and potential protection by testosterone propionate, The Journal of Toxicological Sciences, 39, 5, 2014. Crossref

  7. Cao Ji, Yu Lei, Zhao Jinlong, Ma Haitian, Effect of dehydroepiandrosterone on the immune function of mice in vivo and in vitro, Molecular Immunology, 112, 2019. Crossref

  8. Zhao Fengyi, Wu Liping, Wang Yue, Liu Lianye, Yang Fei, Sun Yushi, Jiao Xiang, Bao Lingyu, Chen Pu, Liang Qiangrong, Shi Bingyin, Dihydrotestosterone regulates oxidative stress and immunosuppressive cytokines in a female BALB/c mouse model of Graves’ disease, Autoimmunity, 52, 3, 2019. Crossref

  9. Usman Taofeek O., Olatunji Lawrence A., Late gestational testosterone exposure causes glucose deregulation and elevated cardiac VCAM-1 and DPP-4 activity in rats, Archives of Physiology and Biochemistry, 127, 5, 2021. Crossref

  10. Ahmed Yasmine H., AbuBakr Huda O., Ahmad Ismail M., Ahmed Zainab Sabry Othman, Histopathological, Immunohistochemical, And Molecular Alterations In Brain Tissue And Submandibular Salivary Gland Of Atrazine-Induced Toxicity In Male Rats, Environmental Science and Pollution Research, 29, 20, 2022. Crossref

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