Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Lymphocytes, Lymphokines, and Silicosis
RÉSUMÉ
Silicosis is characterized by mononuclear cell aggregation with mineral particles and fibrosis.Lymphocytes are abundant in these lesions.We exposed inbred strains of mice to a respirable aerosol of cristobalite silica (70 mg/m3, 5 h/d, 12 d) or shamair. Silicosis evolved over months after exposure. The silica-exposed mice showed the accumulation of lymphocytes in alveolar spaces (seen in bronchoalveolar lavage), in lung parenchymal lesions and nodules, and in enlarged bronchial-associated lymphoid tissues and thoracic lymph nodes. The lung lymphocytes were predominantly CD4+T cells, but numerous CD8+ T cells, natural killer cells, and CD4– gd–TCR+ T cells were present as well. Interferon-g (IFN-g) production was upregulated, suggesting a THelper-1-like response in silicosis. In silicotic lung tissue, mRNA transcripts for the macrophage-derived cytokines IL-12 and -18 were increased. IFN-g gene-deleted mice (C57Bl/6-Ifngtm1Ts) exposed to silica developed less extensive silicosis and less lung collagen accumulation than wild-type mice.We hypothesize that there is a reiterative amplification cycle in which macrophages with silica may produce cytokines, such as IL-12 and -18, that attract and activate lymphocytes. These activated lymphocytes may then produce additional mediators that in turn attract and activate an expanded secondary population of macrophages. IFN-g would be a likely cause of macrophage activation in this cycle. More work is needed to understand the biological events that lead from the inhaled dust to the scarred lung, and to clarify the role of lymphocytes in this process.
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Brown Jared M., Pfau Jean C., Pershouse Mark A., Holian Andrij, Silica, Apoptosis, and Autoimmunity, Journal of Immunotoxicology, 1, 3-4, 2005. Crossref
-
Prakova Gospodinka, Gidikova Pavlina, Slavov Emil, Sandeva Gergana, Stanilova Spaska, Serum neopterin in workers exposed to inorganic dust containing free crystalline silicon dioxide, Open Medicine, 4, 1, 2009. Crossref
-
Kawasaki Hajime, A mechanistic review of silica-induced inhalation toxicity, Inhalation Toxicology, 27, 8, 2015. Crossref
-
Huaux François, Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles, in Inhalation Toxicology, Second Edition, 2005. Crossref
-
Finckh Axel, Cooper Glinda S., Chibnik Lori B., Costenbader Karen H., Watts Julie, Pankey Helen, Fraser Patricia A., Karlson Elizabeth W., Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women, Arthritis & Rheumatism, 54, 11, 2006. Crossref
-
Gulumian M., Borm P. J. A., Vallyathan V., Castranova V., Donaldson K., Nelson G., Murray J., Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review, Journal of Toxicology and Environmental Health, Part B, 9, 5, 2006. Crossref
-
Stanilova S., Miteva L., Prakova G., Interleukin-12B-3'UTR polymorphism in association with IL-12p40 and IL-12p70 serum levels and silicosis severity, International Journal of Immunogenetics, 34, 3, 2007. Crossref
-
Velard Frédéric, Braux Julien, Amedee Joëlle, Laquerriere Patrice, Inflammatory cell response to calcium phosphate biomaterial particles: An overview, Acta Biomaterialia, 9, 2, 2013. Crossref
-
Mossman Brooke T., Glenn Robert E., Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs), Critical Reviews in Toxicology, 43, 8, 2013. Crossref
-
Grandjean-Laquerriere Alexia, Laquerriere Patrice, Laurent-Maquin Dominique, Guenounou Moncef, Phillips Terry M., The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro, Biomaterials, 25, 28, 2004. Crossref
-
Liu Fangwei, Liu Jie, Weng Dong, Chen Ying, Song Laiyu, He Qincheng, Chen Jie, Unutmaz Derya, CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice, PLoS ONE, 5, 11, 2010. Crossref
-
Mielke Stefan, Taeger Dirk, Weitmann Kerstin, Brüning Thomas, Hoffmann Wolfgang, Influence of quartz exposure on lung cancer types in cases of lymph node–only silicosis and lung silicosis in German uranium miners, Archives of Environmental & Occupational Health, 73, 3, 2018. Crossref
-
Misson Pierre, Brombacher Frank, Delos Monique, Lison Dominique, Huaux Francois, Type 2 immune response associated with silicosis is not instrumental in the development of the disease, American Journal of Physiology-Lung Cellular and Molecular Physiology, 292, 1, 2007. Crossref
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Lo Re Sandra, Yakoub Yousof, Devosse Raynal, Uwambayinema Francine, Couillin Isabelle, Ryffel Bernard, Marbaix Etienne, Lison Dominique, Huaux François, Thatcher Thomas H., Uncoupling between Inflammatory and Fibrotic Responses to Silica: Evidence from MyD88 Knockout Mice, PLoS ONE, 9, 7, 2014. Crossref
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Tashiro Jun, Rubio Gustavo A., Limper Andrew H., Williams Kurt, Elliot Sharon J., Ninou Ioanna, Aidinis Vassilis, Tzouvelekis Argyrios, Glassberg Marilyn K., Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis, Frontiers in Medicine, 4, 2017. Crossref
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Carneiro Priscila J., Clevelario Amanda L., Padilha Gisele A., Silva Johnatas D., Kitoko Jamil Z., Olsen Priscilla C., Capelozzi Vera L., Rocco Patricia R. M., Cruz Fernanda F., Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis, Frontiers in Physiology, 8, 2017. Crossref
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Lo Re Sandra, Dumoutier Laure, Couillin Isabelle, Van Vyve Charlotte, Yakoub Yousof, Uwambayinema Francine, Marien Benoît, van den Brûle Sybille, Van Snick Jacques, Uyttenhove Catherine, Ryffel Bernard, Renauld Jean-Christophe, Lison Dominique, Huaux François, IL-17A–Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis, The Journal of Immunology, 184, 11, 2010. Crossref
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McDaniel Dylan K., Ringel-Scaia Veronica M., Morrison Holly A., Coutermarsh-Ott Sheryl, Council-Troche McAlister, Angle Jonathan W., Perry Justin B., Davis Grace, Leng Weinan, Minarchick Valerie, Yang Yi, Chen Bo, Reece Sky W., Brown David A., Cecere Thomas E., Brown Jared M., Gowdy Kymberly M., Hochella Michael F., Allen Irving C., Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function, Frontiers in Immunology, 10, 2019. Crossref
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KUMAGAI Naoko, NISHIMURA Yasumitsu, MAEDA Megumi, HAYASHI Hiroaki, OTSUKI Takemi, Immunological Effects of Silica/Asbestos, Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) , 65, 4, 2010. Crossref
-
Hubbard Andrea K., Mowbray Sarah, Thibodeau Michael, Giardina Charles, Silica-Induced Inflammatory Mediators and Pulmonary Fibrosis, in Fibrogenesis: Cellular and Molecular Basis, 2005. Crossref
-
Lee Suni, Honda Machiko, Yamamoto Shoko, Kumagai-Takei Naoko, Yoshitome Kei, Nishimura Yasumitsu, Sada Nagisa, Kon Shigeyuki, Otsuki Takemi, Role of Nephronectin in Pathophysiology of Silicosis, International Journal of Molecular Sciences, 20, 10, 2019. Crossref
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Martin Keith R., Silicon: The Health Benefits of a Metalloid, in Interrelations between Essential Metal Ions and Human Diseases, 13, 2013. Crossref
-
Zou Jimin, du Prel Carroll Xianming, Liang Xianhong, Wang Dongmei, Li Chao, Yuan Baojun, Leeper-Woodford Sandra, Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study, Environmental Health, 10, 1, 2011. Crossref
-
Langley Raymond J., Kalra Roma, Mishra Neerad C., Hahn Fletcher F., Razani-Boroujerdi Seddigheh, Singh Shashi P., Benson Janet M., Peña-Philippides Juan Carlos, Barr Edward B., Sopori Mohan L., A Biphasic Response to Silica, American Journal of Respiratory Cell and Molecular Biology, 30, 6, 2004. Crossref
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Barbarin Virginie, Arras Mohammed, Misson Pierre, Delos Monique, McGarry Bridget, Phan Sem H., Lison Dominique, Huaux François, Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice, American Journal of Respiratory Cell and Molecular Biology, 31, 1, 2004. Crossref
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Lv Jiaqi, Xiao Jingwei, Jia Qiang, Meng Xiangjing, Yang Zhifeng, Pu Shuangshuang, Li Ming, Yu Tao, Zhang Yi, Wang Haihua, Liu Li, Li Zhongsheng, Chen Xiao, Yang Haitao, Li Yulu, Qiao Mengyun, Duan Airu, Shao Hua, Li Bin, Identification of key pathways and genes in the progression of silicosis based on WGCNA, Inhalation Toxicology, 2022. Crossref
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Fee Lanette, Kumar Advika, Tighe Robert M., Foster Mary H., Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice, Frontiers in Immunology, 13, 2022. Crossref