Abonnement à la biblothèque: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Accéder(open in a new tab)
Suite
Achat $50.00(open in a new tab) Vérifier l'abonnement Télécharger l'archive MARC(open in a new tab) Obtenir des autorisations(open in a new tab)

Neferine Inhibits 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis by Suppression of Cell Proliferation and Induction of Apoptosis via Modulation of the PI3K/AKT/NF-κB Signaling Pathway

Volume 40, Numéro 3, 2021, pp. 51-61
DOI: 10.1615/JEnvironPatholToxicolOncol.2021038118
Get accessGet access
Linhan Yang
Department of Outpatient, Chengdu Aurora Huan Hua Xiang, Chengdu, Sichuan, 610072, China
Ying Xiong
Department of Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China
Zhongli Sun
Department of Pharmacy, Liaocheng People's Hospital, Liaocheng City, 252000, China
Xiaoying Lin
Department of General Surgery, Fujian Provincial Hospital South Branch, Fuzhou City, 350028, China
Huaikun Ni
Department of General Surgery, Fujian Provincial Hospital South Branch, Fuzhou City, 350028, China

RÉSUMÉ

Aim: To investigate the anticancer mechanism of neferine on DMBA-prompted mammary tumorigenesis in animals.
Methods: Mammary cancer was prompted by the subcutaneous injection of 25 mg DMBA mixed in 1 ml of the vehicle (sunflower oil [0.5 ml] and saline [0.5 ml]). We analyzed the biochemical and molecular expression of cell-proliferation and apoptotic markers in normal and DMBA-induced rats.
Results: We detected low body weight, elevated quantities of lipid peroxidation, and low antioxidant enzyme activities in mammary tissues of DMBA-induced animals. We also found an invasive ductal carcinoma in DMBA-induced animals by histopathological assessment. Furthermore, western blotting findings displayed an augmented expression of PI3K, AKT, NF-κB, PCNA, cyclin D1, Ki-67, and Bcl-2, while reducing expression of p53, Bax, caspase-3, and caspase-9 in DMBA-induced cancer-bearing animals. RT-PCR results found upregulation of cyclin D1, PCNA, and Ki-67, and reduced expression of p53 in DMBA-prompted animals. The oral administration of neferine effectually inhibited mammary tumors via improved antioxidants and prevented lipid peroxidation activities when compared with tumor-bearing rats. Furthermore, neferine also modulated PI3K/AKT/NF-κB signaling through inhibiting cell proliferation and induced apoptosis in tumor-bearing rats.
Conclusion: In our findings, we concluded that neferine has an anti-proliferative and enhancing apoptotic property against DMBA-induced mammary cancer.

MOTS CLÉS: mammary cancer, 7, 12-dimethylbenz(a)anthracene, neferine, apoptosis, cell proliferation
RÉFÉRENCES

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.

  2. Jitariu AA, Cimpean AM, Ribatti D, Raica M. Triple negative breast cancer: The kiss of death. Oncotarget. 2017;8:46652-62.

  3. Akhouri V, Kumari M, Kumar A. Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats. Sci Rep. 2020;10:18016.

  4. Dang DK, Shin EJ, Nam Y, Ryoo S, Jeong JH, Jang CG, Nabeshima T, Hong JS, Kim HC. Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK. J Neuroinflammation. 2016;13:1-22.

  5. Christov K, Grubbs CJ, Shilkaitis A, Juliana MM, Lubet RA. Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer model. Clin Cancer Res. 2007;13:5488-96.

  6. Su Z, Yang Z, Xu Y, Chen Y, Yu Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer. 2015;14:48.

  7. Chen M, Wang J. Initiator caspases in apoptosis signaling pathways. Apoptosis. 2002;7:313-19.

  8. An W, Lai H, Zhang Y, Liu M, Lin X, Cao S. Apoptotic pathway as the therapeutic target for anticancer traditional Chinese medicines. Front Pharmacol. 2019;10:758.

  9. Marthandam Asokan S, Mariappan R, Muthusamy S, Velmurugan BK. Pharmacological benefits of neferine: A comprehensive review. Life Sci. 2018;199:60-70.

  10. Zhang X, Liu Z, Xu B, Sun Z, Gong Y, Shao C. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur J Pharmacol. 2012;677:47-54.

  11. Poornima P, Quency RS, Padma VV. Neferine induces re-active oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food Chem. 2013;136:659-67.

  12. Poornima P, Weng CF, Padma VV. Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. Food Chem. 2013;141:3598-605.

  13. An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G. Neferine induces apoptosis by modulating the ROS-mediated JNK pathway in esophageal squamous cell carcinoma. Oncol Rep. 2020;44:1116-26.

  14. Poornima P, Weng CF, Padma VV. Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest. Biofactors. 2014;40:121-31.

  15. Kalai Selvi S, Vinoth A, Varadharajan T, Weng CF, Vijaya Padma V. Neferine augments therapeutic efficacy of cisplatin through ROS-mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells). Food Chem Toxicol. 2017;103:28-40.

  16. Jung HA, Karki S, Kim JH, Choi JS. BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos. Arch Pharm Res. 2015;38:1178-87.

  17. Zhong Y, He S, Huang K, Liang M. Neferine suppresses vascular endothelial inflammation by inhibiting the NF-KB signaling pathway. Arch Biochem Biophys. 2020;696:108595.

  18. Kadioglu O, Law BY, Mok SW, Xu SW, Efferth T, Wong VK. Mode of action analyses of neferine, a bisbenzylisoquinoline alkaloid of lotus (Nelumbo nucifera) against multidrug-resistant tumor cells. Front Pharmacol. 2017;8:238.

  19. Yang D, Zou X, Yi R, Liu W, Peng D, Zhao X. Neferine increase in vitro anticancer effect of dehydroepiandrosterone on MCF-7 human breast cancer cells. Appl Biol Chem. 2016;59:585-96.

  20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Bio-chem. 1979;95:351-8.

  21. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992;202:384-9.

  22. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione peroxidase. Science. 1973;179:588-90.

  23. Kakkar P, Das B, Viswanathan PN. A modified spectro-photometric assay of superoxide dismutase. Indian J Bio-chem Biophys. 1984;21:130-2.

  24. Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972;47:389-94.

  25. Beutler E, Kelly BM. The effect of sodium nitrite on red cell GSH. Experientia. 1963;19:96-7.

  26. Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 1979;62:3-11.

  27. Desai ID. Vitamin E analysis methods for animal tissues. Methods Enzymol. 1984;105:138-47.

  28. Annamalai G, Suresh K. [6]-Shogaol attenuates inflam-mation, cell proliferation via modulate NF-KB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomed Pharmacother. 2018;98:484-90.

  29. Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Res Treat. 2000;63:117-31.

  30. Purushothaman A, Nandhakumar E, Sachdanandam P. Modulation of lipid peroxidation and antioxidant status upon administration of "Shemamruthaa" in 7,12-dimethylbenz[a]anthracene induced mammary carcinoma bearing rats. Asian Pac J Trop Biomed. 2012;2:S765-71.

  31. Padmavathi R, Senthilnathan P, Chodon D, Sakthisekaran D. Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12dimethyl-benz(a)anthracene-induced breast cancer in female Sprague Dawley rats. Life Sci. 2006;78:2820-5.

  32. Lakshmi A, Subramanian S. Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7,12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. Biochimie. 2014;99:96-109.

  33. Khan A, Bai H, Khan A, Bai Z. Neferine prevents ultraviolet radiation-induced skin photoaging. Exp Ther Med. 2020;19:3189-96.

  34. Khan KH, Yap TA, Yan L, Cunningham D. Targeting the PI3K-AKT-mTOR signaling network in cancer. Chin J Cancer. 2013;32:253-65.

  35. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 2003;23:363-98.

  36. Sivalingam K, Amirthalingam V, Ganasan K, Huang CY, Viswanadha VP. Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats. Food Chem Toxicol. 2019;123:385-98.

  37. Ray RS, Ghosh B, Rana A, Chatterjee M. Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: Chemopreventive activity of vanadium in vivo and in vitro. Int J Cancer. 2007;120:13-23.

  38. Kathiresan S, Govindhan A. [6]-Shogaol, a novel chemopreventor in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Phytother Res. 2016;30:646-53.

  39. Han S, Woo JK, Jung Y, Jeong D, Kang M, Yoo YJ, Lee H, Oh SH, Ryu JH, Kim WY. Evodiamine selectively targets cancer stemlike cells through the p53-p21-Rb pathway. Biochem Biophys Res Commun. 2016;469:1153-8.

  40. Al-Dhaheri WS, Hassouna I, Al-Salam S, Karam SM. Characterization of breast cancer progression in the rat. Ann N Y Acad Sci. 2008;1138:121-31.

  41. Ahmed ST, Ahmed AM, Musa DH, Sulayvani FK, Al-Khyatt M, Pity IS. Proliferative index (Ki67) for prediction in breast duct carcinomas. Asian Pac J Cancer Prev. 2018;19:955-9.

  42. Jang TJ, Kang MS, Kim H, Kim DH, Lee JI, Kim JR. Increased expression of cyclin D1, cyclin E and p21(Cip1) associated with decreased expression of p27(Kip1) in chemically induced rat mammary carcinogenesis. Jpn J Cancer Res. 2000;91:1222-32.

  43. Annamalai G, Kathiresan S, Kannappan N. [6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells. Biomed Pharmacother. 2016;82:226-36.

  44. Jamalzadeh L, Ghafoori H, Aghamaali M, Sariri R. Induction of apoptosis in human breast cancer MCF-7 cells by a semi-synthetic derivative of artemisinin: A caspase-related mechanism. Iran J Biotechnol. 2017;15:157-65.

  45. Kumar RN, Kumar KN, Salini K, Devaraj SN. Morin accelerates proliferative inhibition via NF-KB mediated transcriptional regulation of apoptotic events during chemical carcinogen induced mammary cancer in rats. Biomed Prev Nutr. 2014;4:277-90.

CITÉ PAR

  1. He Jinshan, Li Sicong, Ding Yumeng, Tong Yujia, Li Xuebin, Saponara Simona, Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels, Cardiovascular Therapeutics, 2022, 2022. Crossref

  2. Ren Yu, He Jinying, Zhao Wenhua, Ma Yuzhen, The Anti-Tumor Efficacy of Verbascoside on Ovarian Cancer via Facilitating CCN1-AKT/NF-κB Pathway-Mediated M1 Macrophage Polarization, Frontiers in Oncology, 12, 2022. Crossref

  3. Hritcu Lucian, Cioanca Oana, Therapeutic Molecular Targets of Cancer and Animal Models: Adequacy and Drawbacks, in Handbook of Animal Models and its Uses in Cancer Research, 2022. Crossref

1549 Vues d'articles 29 Téléchargements d'articles Métrique
1549 VUES 29 TÉLÉCHARGEMENTS 3 Crossref CITATIONS Google
Scholar CITATIONS

Articles avec un contenu similaire:

Mangiferin Inhibits Inflammation and Cell Proliferation, and Activates Proapoptotic Events via NF-κB Inhibition in DMBA-Induced Mammary Carcinogenesis in Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.40, 2021, issue 2
Xin Wang, Tong Yuwen, Tian Yanqin
Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 1
Zhanzhan Xiao, Elamaran Ananda Jothi, Huazhi Zhang, Ping Lv, Jiangfei Yang
Anticancer Effect of Troxerutin in Human Non-Small-Cell Lung Cancer Cell A549 and Inhibition of Tumor Formation in BALB/c Nude Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.40, 2021, issue 3
Junlong Yu, Sulaiman Ali Alharbi, Min Cao, Ling Qian, Xiaohan Huang, Jinni Jian, Lili Shao, Arunachalam Chinnathambi
Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 2
Qing Wang, Meifang Huang, Yuanyuan Zheng, Kai Zheng, Liqiong Zhang
Protective Role of Curcumin and Flunixin Against Acetic Acid−Induced Inflammatory Bowel Disease via Modulating Inflammatory Mediators and Cytokine Profile in Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
G BOOBALAN, Matukumalli Usha Rani, C.S.V. Satish Kumar, Alla Gopala Reddy, Rasakatla Dileep, Matham Vijay Kumar

Dernier numéro

A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy Sanjib Bhattacharya Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis Congkun Lou, Wenhsin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer Deqin Liu, Renyin Luo, Qian Zhou, Mei Li Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape Jian Zhu, Yao Ma

Prochains articles

LncRNA LINC01278 regulates the prognosis and related mechanisms of gastric cancer by targeting miR-129-5p Zhenhua Wang, Zhengliang Li, Xiaojing Liu, Jundong Wang, Jiaxi Wang, Guoxiang Jiang, Haizhou Yu FBXO45 expression levels Correlation with cancer severity by ZEB1 ubiquitin in non-small cell lung cancer Bingwei Dong LncRNA AGAP11 suppresses lung adenocarcinoma progression by miR-494-3p and predicts prognosis Ye He, Ya Lin , Chunge Dong, Jie Zhang, Yangli Zhu Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis Congkun Lou, Wenxin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala A review on protease inhibitors of herbal origin to combat malignancy Sanjib Bhattacharya
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain