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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v1.i1-2.80
pages 115-125

Computational Evaluation of Yin Yang 1 Transcript Levels in the Spectrum of B-cell Neoplasia

Massimo Libra
Section of Clinical Pathology and Molecular Oncology, Department of Biomedical Sciences, University of Catania, Catania, Italy
Elena Torrisi
Department of Biomedical Sciences, University of Catania, Catania
Giancarlo Castellano
Department of Biomedical Sciences, University of Catania, Catania
Ferdinando Nicoletti
Section of Clinical Pathology and Molecular Oncology, Department of Biomedical Sciences, University of Catania, Catania, Italy
Grazia Malaponte
Department of Biomedical Sciences, University of Catania, Catania
Maria C. Mazzarino
Department of Biomedical Sciences, University of Catania, Catania
Andrea Marconi
Section of Clinical Pathology and Molecular Oncology, Department of Biomedical Sciences; and Section of Occupational Medicine, Department of Internal Medicine, University of Catania, Italy
Lidia Proietti
Section of Occupational Medicine, Department of Internal Medicine, University of Catania, Italy
Loredana Militello
Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA
Benjamin Bonavida
Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90025-1747
Franca Stivala
Section of Clinical Pathology and Molecular Oncology, Department of Biomedical Sciences, University of Catania, Catania, Italy
Silvana Canevari
Fondazione IRCCS Istituto Nazionale dei Tumori; Unit of Molecular Therapies, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

RÉSUMÉ

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lympho-proliferative malignancies with variable patterns of behavior and response to treatments. Although many patients respond to conventional therapies, many relapse and become refractory to further treatments. Studies using B-NHL cell lines have shown that the Yin Yang 1 (YY1) transcription factor is implicated in the regulation of resistance to both chemotherapeutic and immunotherapeutic drugs. This study examined the involvement of YY1 in the spectrum of B-cell neoplasia. The transcript levels of YY1 were evaluated using two different data sets of publicly available microarrays for lymphoma tumor biopsy specimens. The findings revealed that YY1 expression levels increased in association with B-cell transformation, suggesting that YY1 may be involved in B-cell transformation and may give rise to Burkitt's lymphoma and diffuse large B-cell lymphoma.


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