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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v1.i4.40
pages 297-305

Post-Translational Regulation of Fas/CD95 in Cell Death and Survival: Role of Nitric Oxide

L. Leon-Bollotte
EPHE, Laboratoire d'immunologie et immunothérapie des cancers, University of Burgundy, Dijon
M. Lamrani
EPHE, Laboratoire d'immunologie et immunothérapie des cancers, University of Burgundy, Dijon
S. Plenchette-Colas
EPHE, Laboratoire d'immunologie et immunothérapie des cancers, University of Burgundy, Dijon
Jean-Francois Jeannin
EPHE Tumor Immunology and Immunotherapy, Laboratory, University of Burgundy, Dijon, France
Ali Bettaieb
École Pratique des Hautes Études (EPHE), PSL Research University, Paris, France; Laboratoire d'Immunologie et Immunothérapie des Cancers (LIIC), Université de Bourgogne Franche-Comté, Dijon, France

RÉSUMÉ

Fas/CD95 or APO-1 is one of the best-characterized members of the tumor necrosis factor receptor (TNFR) superfamily. Triggering of Fas by its ligand (FasL) leads to receptor oligomerization and the formation of the death-induced signaling complex (DISC), and thereby activates the caspase cascade, which culminates in apoptotic cell death. Many post-translational modifications are recognized as critical modifications for the early events of Fas regulation and function. Here, we summarize the current knowledge on Fas post-translational modifications, including phosphorylation, nitration, palmitoylation, and glutathionylation.


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