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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2012004631
pages 15-39

Treatment of Chemotherapy Induced Peripheral Neuropathy: The Role of Medicinal Herbs

Sven Schroeder
HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Gesa Meyer-Hamme
HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Thomas Friedemann
HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Hamburg, Germany

RÉSUMÉ

Chemotherapy-induced neuropathy (CIPN) is one main dose-limiting toxicity in oncologic treatment. It leads to neuropathic pain and gait impairment and decreases patients' quality of life. Platinum compounds such as taxanes, epothilones, vinca-alkaloids, bortezomib, and taladomide, are the major substances that cause CIPN. Presently, there are no curative conventional treatments for CIPN. Mechanisms of CIPN are not well known, but oxidative stress and mitochondrial dysfunction are involved. The aim of this review is to illuminate the possible role of herbal treatment in CIPN. Chamomile, Acorus calmus and Salvia officinalis show evidence of being effective against neuropathic pain, Gingko biloba and the herbal combination Goshajinkigan (Niu-che-sen-qi-wan) show some evidence of preventing neuronal degeneration in CIPN. Herbal antioxidants and herbs for enhancement of nerve growth as putative treatment options for CIPN are reviewed here. Many promising substances, mainly Chinese medicinal herbs with possible effects on CIPN or a putative influence on mechanisms of CIPN, have been identified in recent years, but no clear clinical recommendation for herbal treatment of CIPN can be provided by this review. Modern research on Chinese medical herbs should not only focus on single components but also on herbal combinations to develop treatments for multifactorial diseases like CIPN.