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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2013008322
pages 11-23

Current Molecular Targeting of Lymphomas

Ryouichi Horie
1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan


A typical discrepancy exists between the classification of and treatment strategies for lymphomas. The identification of key molecules in subtypes of lymphomas and the development of molecular targeted strategies will fill this gap. Pathological characteristics might be the consequence of deregulated molecular patterns in lymphomas. Therefore, exploration of addictive molecules based on the pathological classification might be an efficient way to establish molecular targeted therapy for lymphomas. The chromosomal translocation characterizing the subtypes of lymphomas and molecular characteristics for each subtype may suggest a molecular biological approach to identifying addictive molecules to be targeted. This review highlights the potential molecular targets in oncogenic signaling pathways in lymphomas.

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