Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2013008306
pages 43-51

Molecular Targets for Suppression of Metastasis: Recent Cellular Observations

Siro Simizu
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
Yuki Niwa
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan

RÉSUMÉ

Cancer metastasis is regulated by many factors. In this review article, we introduce novel molecular targets for the suppression of cancer metastasis. Dehydroxymethylepoxyquinomicin (DHMEQ) is a specific inhibitor of NF-κB that inhibits many types of cancer cell growth in vivo. Recently, DHMEQ was reported to suppress cell invasion in an ovarian cancer cell line due to the deregulation of the autocrine system of CXCL12/ CXCR4. An ATP-sensitive K+ channel blocker, glybenclamide, has been reported to suppress PDGF secretion, thereby inhibiting cell migration in ovarian cancer. Other emerging molecular targets are glycosaminoglycan (GAG)-degrading enzymes, such as heparanase and hyaluronidases. These inhibitors have been shown to suppress cancer cell metastasis both in vitro and in vivo. We previously reported the important role of protein glycosylation for metastasis-related protein functions. Thus, we hypothesize that NF-κB, K+ channels, GAG-degrading enzymes, and protein glycosylation may be useful targets for suppression of metastasis.


Articles with similar content:

Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis
Critical Reviews™ in Immunology, Vol.20, 2000, issue 2
John E. Eriksson, Tim H. Holmstrom
Role of c-MET in Upper Aerodigestive Malignancies — From Biology to Novel Therapies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 3
Radha Uppalapati, Tanguy Y. Seiwert, Sascha Dietrich, Patrick C. Ma
Role of Diacylglycerol Kinases in T Cell Development and Function
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Sruti Krishna , Xiaoping Zhong
Roles of Smad3 in TGF-β Signaling During Carcinogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 4
Caroline Millet, Ying E. Zhang
mTOR Signaling in Cancer Cell Motility and Tumor Metastasis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 1
Hongyu Zhou, Shile Huang