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Journal of Long-Term Effects of Medical Implants
SJR: 0.133 SNIP: 0.491 CiteScore™: 0.89

ISSN Imprimer: 1050-6934
ISSN En ligne: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v19.i4.90
pages 323-329

Manufacture of Nanoparticles from Bone: A Preliminary Study

Stephen J. Florczyk
Materials Science and Engineering Department, University of Washington, Seattle, WA, USA
Subrata Saha
Affiliate Professor, Department of Restorative Dentistry Affiliate Instructor, Department of Oral and Maxillofacial Surgery School of Dentistry, University of Washington, Seattle, Washington 98195-6365, USA; Courtesy Professor, Department of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA


This study investigated a mechanical processing method using vibratory milling to reduce the particle size of bone ash to produce hydroxyapatite (HA) nanoparticles from bovine bone. Bovine femurs were cleaned of soft tissue, cut into small pieces, heated to 600°C for 24 h, and ground into a coarse powder. A 50 wt% suspension was prepared, vibratory milled for 18 h, and then the milled suspension was filter pressed, dried, and ground into powder. The powder was analyzed with scanning electron microscopy and X-ray diffraction, which confirmed the particle size and the chemical composition of the powder-matched HA. The results of this study qualitatively showed that it is possible to produce HA nanoparticles from bone. This research explores a "green" manufacturing process that reuses a scrap material from the food industry and reduces the use of chemical precursors for synthetic nanoparticle synthesis. Such HA powder can potentially be used as a bone substitute and for coating orthopedic and dental implants.