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Journal of Long-Term Effects of Medical Implants
SJR: 0.145 SNIP: 0.491 CiteScore™: 0.89

ISSN Imprimer: 1050-6934
ISSN En ligne: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.2020034793
pages 281-288

Histologic and Histomorphometric Assessment of Xenograft Bone Substitute versus Synthetic Nonceramic Hydroxyapatite for Canine Tooth-Socket Preservation

Mahdi Kadkhodazadeh
Dentofacial Deformities Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Sohrabi
Dental School, Kermanshah University of Medical Sciences, Tehran, Iran
Mohammad Reza Abrishami
Department of Periodontics, Shahid Beheshti Dental School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran
Reza Amid
Department of Periodontics, Shahid Beheshti Dental School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran
Fatemeh Mashhadiabbas
Department of Oral Pathology, Shahid Beheshti Dental School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran
Narges Shojaei
Department of Periodontics, Shahid Beheshti Dental School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran
Mohammad Mehdi Dehghan
Institute of Biomedical Research, University of Tehran, Tehran, Iran; Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Faezeh Faghihi
Department of Periodontics, Shahid Beheshti Dental School, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran


This study sought to histologically and histomorphometrically assess and compare application of xenograft bone substitute and synthetic nonceramic hydroxyapatite for tooth-socket preservation in dogs. This split-mouth clinical trial was conducted in five hybrid dogs, using four tooth sockets in each dog, with a total of 20 sockets for evaluation. Group 1 received xenografts, and group 2 received synthetic nonceramic hydroxyapatite in the sockets. In group 3 (positive controls), sockets remained empty. All sockets were covered with collagen resorbable membrane, and the flap was stitched using nonresorbable sutures. In group 4 (negative control), sockets were without membrane, left empty, and sutured. After 12 wk, 8-mm-high bone core biopsies were harvested from inside the sockets, using a trephine bur with an internal diameter of 2 mm. We assessed the tissue in terms of percentage of newly formed viable bone, percentage of remaining particles, degree of inflammation, and type of connective tissue. Data were statistically analyzed. The percentage of newly formed viable bone was 34.98% in group 1 and 41.30% in group 2, and this difference was not statistically significant (p = 0.710). The percentage of remaining particles was 15.95% in group 1 and 14.14% in group 2; this difference was also not statistically significant (p = 0.902). Both synthetic nonceramic hydroxyapatite and xenograft bone substitute showed similar efficacy, histologically and histomorphometrically, when used with resorbable collagen membrane for tooth-socket preservation in dogs.


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