Publication de 4 numéros par an
ISSN Imprimer: 1050-6934
ISSN En ligne: 1940-4379
Indexed in
Cardiovascular Tissue Engineering I. Perfusion Bioreactors: A Review
Get access
RÉSUMÉ
Tissue engineering is a fast-evolving field of biomedical science and technology with future promise to manufacture living tissues and organs for replacement, repair, and regeneration of diseased organs. Owing to the specific role of hemodynamics in the development, maintenance, and functioning of the cardiovascular system, bioreactors are a fundamental of cardiovascular tissue engineering. The development of perfusion bioreactor technology for cardiovascular tissue engineering is a direct sequence of previous historic successes in extracorporeal circulation techniques. Bioreactors provide a fluidic environment for tissue engineered tissue and organs, and guarantee their viability, maturation, biomonitoring, testing, storage, and transportation. There are different types of bioreactors and they vary greatly in their size, complexity, and functional capabilities. Although progress in design and functional properties of perfusion bioreactors for tissue engineered blood vessels, heart valves, and myocardial patches is obvious, there are some challenges and insufficiently addressed issues, and room for bioreactor design improvement and performance optimization. These challenges include creating a triple perfusion bioreactor for vascularized tubular tissue engineered cardiac construct; designing and manufacturing fluidics-based perfused minibioreactors; incorporation of systematic mathematical modeling and computer simulation based on computational fluid dynamics into the bioreactor designing process; and development of automatic systems of hydrodynamic regime control. Designing and engineering of built-in noninvasive biomonitoring systems is another important challenge. The optimal and most efficient perfusion and conditioning regime, which accelerates tissue maturation of tissue-engineered constructs also remains to be determined. This is a first article in a series of reviews on critical elements of cardiovascular tissue engineering technology describing the current status, unsolved problems, and challenges of bioreactor technology in cardiovascular tissue engineering and outlining future trends and developments.
-
Hansmann Jan, Groeber Florian, Kahlig Alexander, Kleinhans Claudia, Walles Heike, Bioreactors in tissue engineering-principles, applications and commercial constraints, Biotechnology Journal, 8, 3, 2013. Crossref
-
Mun Cho Hay, Jung Youngmee, Kim Sang-Heon, Kim Hee Chan, Kim Soo Hyun, Effects of Pulsatile Bioreactor Culture on Vascular Smooth Muscle Cells Seeded on Electrospun Poly (lactide-co-ε-caprolactone) Scaffold, Artificial Organs, 37, 12, 2013. Crossref
-
Mironov Vladimir, Prestwich Glenn, Forgacs Gabor, Bioprinting living structures, Journal of Materials Chemistry, 17, 20, 2007. Crossref
-
Rezende R. A., Selishchev S. V., Kasyanov V. A., da Silva J. V. L., Mironov V. A., An Organ Biofabrication Line: Enabling Technology for Organ Printing. Part II: from Encapsulators to Biofabrication Line, Biomedical Engineering, 47, 4, 2013. Crossref
-
Bioreactors for Tissue Engineering, in Introduction to Tissue Engineering, 2014. Crossref
-
Kasyanov Vladimir A., Hodde Jason, Hiles Michael C., Eisenberg Carol, Eisenberg Leonard, De Castro Luis E. F., Ozolanta Iveta, Murovska Modra, Draughn Robert A., Prestwich Glenn D., Markwald Roger R., Mironov Vladimir, Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized natural scaffold with laser-machined micropores, Journal of Materials Science: Materials in Medicine, 20, 1, 2009. Crossref
-
Shaikh Faisal M., O'Brien Thomas P., Callanan Anthony, Kavanagh Eamon G., Burke Paul E., Grace Pierce A., McGloughlin Timothy M., New Pulsatile Hydrostatic Pressure Bioreactor for Vascular Tissue-engineered Constructs, Artificial Organs, 34, 2, 2010. Crossref
-
Marga Francoise, Jakab Karoly, Khatiwala Chirag, Shepherd Benjamin, Dorfman Scott, Hubbard Bradley, Colbert Stephen, Gabor Forgacs, Toward engineering functional organ modules by additive manufacturing, Biofabrication, 4, 2, 2012. Crossref
-
Furth Mark E., Atala Anthony, Future Perspectives, in Principles of Tissue Engineering, 2007. Crossref
-
Mironov Vladimir, Rezende Rodrigo A., Kasyanov Vladimir, da Silva Jorge V.L., Virtual Biofabrication Line, IFAC Proceedings Volumes, 46, 24, 2013. Crossref
-
Distler Thomas, Ruther Florian, Boccaccini Aldo R., Detsch Rainer, Development of 3D Biofabricated Cell Laden Hydrogel Vessels and a Low‐Cost Desktop Printed Perfusion Chamber for In Vitro Vessel Maturation, Macromolecular Bioscience, 19, 9, 2019. Crossref
-
Mertsching H., Hansmann J., , 2008. Crossref
-
West Jennifer L., Biomaterials for Cardiovascular Tissue Engineering, in Biomaterials Science, 2020. Crossref
-
Camasão Dimitria B., Li Ling, Drouin Bernard, Lau Cori, Reinhardt Dieter P., Mantovani Diego, Physiologically relevant platform for an advanced in vitro model of the vascular wall: focus on in situ fabrication and mechanical maturation, In vitro models, 1, 2, 2022. Crossref