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Journal of Long-Term Effects of Medical Implants

Publication de 4  numéros par an

ISSN Imprimer: 1050-6934

ISSN En ligne: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

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Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study

Volume 21, Numéro 2, 2011, pp. 159-167
DOI: 10.1615/JLongTermEffMedImplants.v21.i2.60
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RÉSUMÉ

Bone defects resulting from trauma or pathology represent a common and significant clinical problem. In this study, hydroxyapatite (HAp)-alumina bi-layered scaffolds, which have the benefits of both HAp (i.e., osteointegration, osteoconduction) and alumina (i.e., hardness) were used as a bone substitute for the repair of large segmental defects (20 mm) created in a beagle tibia model. Highly porous bi-layered scaffolds with isotropic-pore structures were fabricated using a polymer-template coating technique. The pore sizes obtained using this approach ranged between 230 μm and 470 μm, and porosity was 91.61±1.28%. Using scanning electron microscopy and energy dispersive spectroscopy, it was confirmed that the frame of each bi-layered scaffold consisted of an alumina inner layer and HAp outer layer. The evaluation of bone regeneration within each scaffold after implantation in the beagle tibia was performed using CT, micro-CT, scintigraphy. New bone formation was evident in the large segmental defects treated with HAp/alumina scaffolds. It was concluded from this study that the HAp/alumina bi-layered scaffold is instrumental in inducing host-scaffold engraftment at the distal and proximal ends of the defect as well as distributing the newly formed bone throughout each scaffold 8 weeks post-implantation.

CITÉ PAR
  1. Shi Qin, Li Yang, Sun Jie, Zhang Hua, Chen Lei, Chen Bing, Yang Huilin, Wang Zhaoxu, The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2, Biomaterials, 33, 28, 2012. Crossref

  2. Lin Qiwang, Wang Linhui, Bai Yuling, Hu Menglin, Mo Jianling, He Haixin, Lou Aiju, Yang Bo, Zhao Hongpu, Guo Yuan, Wu Yanfeng, Wang Le, RETRACTED ARTICLE: Effect of the co-culture of human bone marrow mesenchymal stromal cells with human umbilical vein endothelial cells in vitro, Journal of Receptors and Signal Transduction, 36, 3, 2016. Crossref

  3. Kim Jong Min, Son Jun Sik, Kang Seong Soo, Kim Gonhyung, Choi Seok Hwa, Bone Regeneration of Hydroxyapatite/Alumina Bilayered Scaffold with 3 mm Passage-Like Medullary Canal in Canine Tibia Model, BioMed Research International, 2015, 2015. Crossref

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