Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017019158
pages 283-314

The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease

Veronica M. Ringel-Scaia
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061
Dylan K. McDaniel
Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061
Irving C. Allen
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061; Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061

RÉSUMÉ

Recent advances have revealed significant insight into inflammatory bowel disease (IBD) pathobiology. Ulcerative colitis and Crohn's disease, the chronic relapsing clinical manifestations of IBD, are complex disorders with genetic and environmental influences. These diseases are associated with the dysregulation of immune tolerance, excessive inflammation, and damage to the epithelial cell barrier. Increasing evidence indicates that pattern recognition receptors, including Toll-like receptors (TLRs) and nucleotide-binding domain and leucine-rich repeat-containing proteins (NLRs), function to maintain immune system homeostasis, modulate the gastrointestinal microbiome, and promote proper intestinal epithelial cell regeneration and repair. New insights have revealed that NLR family members are essential components in maintaining this immune system homeostasis. To date, the vast majority of studies associated with NLRs have focused on family members that form a multiprotein signaling platform called the inflammasome. These signaling complexes are responsible for the cleavage and activation of the potent pleotropic cytokines IL-1β and IL-18, and they facilitate a unique form of cell death defined as pyroptosis. In this review, we summarize the current paradigms associated with NLR inflammasome maintenance of immune system homeostasis in the gastrointestinal system. New concepts related to canonical and noncanonical inflammasome signaling, as well as the implications of classical and alternative inflammasomes in IBD pathogenesis, are also reviewed.


Articles with similar content:

Muller Glia in Retinal Innate Immunity: A Perspective on Their Roles in Endophthalmitis
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Mamta Kanwar, Lindsay J. Miller, Ashok Kumar, Pawan K. Singh, Rajeev K. Pandey
Therapeutic Targeting of the Epidermal Growth Factor Receptor in Human Cancer
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 1
Nathalie S. Dhomen, Niall Tebbutt, John Mariadason, Andrew M. Scott
The Inflammasome and Its Regulation
Critical Reviews™ in Immunology, Vol.34, 2014, issue 1
Hideki Hara, Kohsuke Tsuchiya
lnterleukin-10 in the Brain
Critical Reviews™ in Immunology, Vol.21, 2001, issue 5
Wen-Hong Shen, Suzanne R. Broussard, Rodney W. Johnson, Robert Dantzer, Klemen Strle, Gregory G. Freund, Keith W. Kelley, Jian-Hua Zhou
The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Wei Su, Gwenn A. Garden, Macarena S. Aloi