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Critical Reviews™ in Immunology

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ISSN Imprimer: 1040-8401

ISSN En ligne: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Immune-Mediated Oligodendrocyte Injury in Multiple Sclerosis: Molecular Mechanisms and Therapeutic Interventions

Volume 22, Numéro 5-6, 2002, 34 pages
DOI: 10.1615/CritRevImmunol.v22.i5-6.30
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Mieke Buntinx
Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Universitaire Campus A, B-3590 Diepenbeek, Belgium
Piet Stinissen
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium
Paul Steels
Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Universitaire Campus A, B-3590 Diepenbeek, Belgium
Marcel Ameloot
Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Universitaire Campus A, B-3590 Diepenbeek, Belgium
Jef Raus
Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and School of Life Sciences, Transnational University Limburg, Universitaire Campus A, B-3590 Diepenbeek, Belgium

RÉSUMÉ

In this review, new insights into the immunopathogenesis of multiple sclerosis (MS) are discussed, with special focus on the potential mechanisms leading to neuroinflammation in MS—that is, the role of autoreactive T cells, infections, and neurodegenerative events. Oligodendrocytes are considered to be the target of autoimmune inflammation in the CNS of MS patients. Some important features of oligodendrocyte biology are discussed, together with the molecular mechanisms that are potentially involved in oligodendrocyte injury. These include injury mechanisms that might be executed by the adaptive and innate immune system, via cytokines and/or oligodendrocyte receptors, or as a consequence of nitrative and oxidative stress, and excitotoxicity. The mode of cell death of oligodendrocytes in MS is discussed, in addition to the mechanisms of axonal injury as observed in pathology- and imaging-based studies. Finally, recent progress in therapeutic strategies that may interfere with these pathological processes are reviewed, with a focus on repair strategies, such as gene therapy, antibody-mediated remyelination, and stem cell therapy.

CITÉ PAR

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  2. Buntinx Mieke, Gielen Ellen, Van Hummelen Paul, Raus Jef, Ameloot Marcel, Steels Paul, Stinissen Piet, Cytokine-induced cell death in human oligodendroglial cell lines. II: Alterations in gene expression induced by interferon-? and tumor necrosis factor-?, Journal of Neuroscience Research, 76, 6, 2004. Crossref

  3. Buntinx Mieke, Moreels Marjan, Vandenabeele Frank, Lambrichts Ivo, Raus Jef, Steels Paul, Stinissen Piet, Ameloot Marcel, Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFN-? and TNF-? on apoptosis, Journal of Neuroscience Research, 76, 6, 2004. Crossref

  4. Vanderlocht Joris, Hellings Niels, Hendriks Jerome J.A., Vandenabeele Frank, Moreels Marjan, Buntinx Mieke, Hoekstra Dick, Antel Jack P., Stinissen Piet, Leukemia inhibitory factor is produced by myelin-reactive T cells from multiple sclerosis patients and protects against tumor necrosis factor-α-induced oligodendrocyte apoptosis, Journal of Neuroscience Research, 83, 5, 2006. Crossref

  5. Lin Wensheng, Bailey Samantha L., Ho Hanson, Harding Heather P., Ron David, Miller Stephen D., Popko Brian, The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage, Journal of Clinical Investigation, 117, 2, 2007. Crossref

  6. Zou Jian, Crews Fulton, CREB and NF-κB Transcription Factors Regulate Sensitivity to Excitotoxic and Oxidative Stress Induced Neuronal Cell Death, Cellular and Molecular Neurobiology, 26, 4-6, 2006. Crossref

  7. Lin Yifeng, Huang Guangcun, Jamison Stephanie, Li Jin, Harding Heather P., Ron David, Lin Wensheng, PERK Activation Preserves the Viability and Function of Remyelinating Oligodendrocytes in Immune-Mediated Demyelinating Diseases, The American Journal of Pathology, 184, 2, 2014. Crossref

  8. Opdenakker Ghislain, Immunohistopathology to guide multiple sclerosis treatment, The Lancet, 366, 9485, 2005. Crossref

  9. Slaets Helena, Dumont Debora, Vanderlocht Joris, Noben Jean-Paul, Leprince Pierre, Robben Johan, Hendriks Jerome, Stinissen Piet, Hellings Niels, Leukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3, PROTEOMICS, 8, 6, 2008. Crossref

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  11. Lin Wensheng, Lin Yifeng, Interferon-γ inhibits central nervous system myelination through both STAT1-dependent and STAT1-independent pathways, Journal of Neuroscience Research, 2010. Crossref

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  13. Dumont Debora, Noben Jean-Paul, Moreels Marjan, Vanderlocht Joris, Hellings Niels, Vandenabeele Frank, Lambrichts Ivo, Stinissen Piet, Robben Johan, Characterization of mature rat oligodendrocytes: a proteomic approach, Journal of Neurochemistry, 102, 2, 2007. Crossref

  14. BRACHET PHILIPPE, NEVEU ISABELLE, NAVEILHAN PHILIPPE, GARCION EMMANUEL, WION DIDIER, Vitamin D, A Neuroactive Hormone: From Brain Development to Pathological Disorders, in Vitamin D, 2005. Crossref

  15. Gowran Aoife, Noonan Janis, Campbell Veronica A., The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration, CNS Neuroscience & Therapeutics, 17, 6, 2011. Crossref

  16. Lin Wensheng, Kunkler Phillip E., Harding Heather P., Ron David, Kraig Richard P., Popko Brian, Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-γ, The American Journal of Pathology, 173, 5, 2008. Crossref

  17. Clanchy Felix IL, Williams Richard O, Plasmid DNA as a safe gene delivery vehicle for treatment of chronic inflammatory disease, Expert Opinion on Biological Therapy, 8, 10, 2008. Crossref

  18. Slaets Helena, Hendriks Jerome J.A., Stinissen Piet, Kilpatrick Trevor J., Hellings Niels, Therapeutic potential of LIF in multiple sclerosis, Trends in Molecular Medicine, 16, 11, 2010. Crossref

  19. Jaffe Russell, First Line Comprehensive Care. Part I: Chronic Autoimmune Disease Management by Causes Rather than Symptomatic Consequences, Seminars in Integrative Medicine, 3, 2, 2005. Crossref

  20. Karussis Dimitrios, Grigoriadis Savas, Polyzoidou Eleni, Grigoriadis Nikolaos, Slavin Shimon, Abramsky Oded, Neuroprotection in multiple sclerosis, Clinical Neurology and Neurosurgery, 108, 3, 2006. Crossref

  21. Yong V. Wee, IMMUNOPATHOGENESIS OF MULTIPLE SCLEROSIS, CONTINUUM: Lifelong Learning in Neurology, 10, 2004. Crossref

  22. Lin Yifeng, Jamison Stephanie, Lin Wensheng, Gallyas Ferenc, Interferon-γ Activates Nuclear Factor-κ B in Oligodendrocytes through a Process Mediated by the Unfolded Protein Response, PLoS ONE, 7, 5, 2012. Crossref

  23. Kuhlmann Tanja, Multiple Sklerose und verwandte Erkrankungen, in Pathologie, 2012. Crossref

  24. Xiao Bao-Guo, Link Hans, Neuroimmunology and immune-related neuropathologies, in Handbook of Experimental Neurology, 2006. Crossref

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