Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Glucocorticoid-Induced Apoptosis in Animal Models of Multiple Sclerosis
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RÉSUMÉ
Glucocorticoids (GCs) are highly potent anti-inflammatory and immunosuppressive agents. They exert influence on many cell types of the immune system and impact a plethora of processes such as cytokine production, leukocyte differentiation, migration and adhesion, apoptosis induction, and changes in morphology. Those that are most relevant for the modulation of neuroinflammatory diseases, however, are still under debate. In this review, we will elaborate on how GCs impact inflammatory responses in general and revisit the ambivalent role that apoptosis plays in animal models of multiple sclerosis. Furthermore, we will discuss arguments that speak in favor or against an essential function of GC-induced apoptosis in neuroinflammation. We anticipate that a better knowledge of the mechanisms that GCs employ will eventually find its way into clinical practice for the future benefit of afflicted patients.
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Bartneck Matthias, Scheyda Katharina M., Warzecha Klaudia T., Rizzo Larissa Y., Hittatiya Kanishka, Luedde Tom, Storm Gert, Trautwein Christian, Lammers Twan, Tacke Frank, Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases, Biomaterials, 37, 2015. Crossref
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Stournaras Christos, Gravanis Achilles, Margioris Andrew N., Lang Florian, The actin cytoskeleton in rapid steroid hormone actions, Cytoskeleton, 71, 5, 2014. Crossref
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Sun Jiafeng, Yu Ning, Li Xiangpei, Wang Li, Pan Yun, Li Xiaomei, Tao Jinhui, Chen Zhu, Wang Guosheng, Aberrant GITR expression on different T cell subsets and the regulation by glucocorticoid in systemic lupus erythematosus, International Journal of Rheumatic Diseases, 19, 2, 2016. Crossref
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Kalafatakis Konstantinos, Russell Georgina M., Zarros Apostolos, Lightman Stafford L., Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics, Neuroscience & Biobehavioral Reviews, 61, 2016. Crossref
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Montes-Cobos Elena, Ring Sarah, Fischer Henrike J., Heck Joachim, Strauß Judith, Schwaninger Markus, Reichardt Sybille D., Feldmann Claus, Lühder Fred, Reichardt Holger M., Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles, Journal of Controlled Release, 245, 2017. Crossref
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Hoepner Robert, Bagnoud Maud, Pistor Maximilian, Salmen Anke, Briner Myriam, Synn Helen, Schrewe Lisa, Guse Kirsten, Ahmadi Farhad, Demir Seray, Laverick Louis, Gresle Melissa, Worley Paul, Reichardt Holger Michael, Butzkueven Helmut, Gold Ralf, Metz Imke, Lühder Fred, Chan Andrew, Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis, Acta Neuropathologica, 138, 3, 2019. Crossref
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Simpson Brittany N., Hogg Nancy, Svensson Lena M., McDowall Alison, Daley William, Yarbrough Kilby, Abdul-Rahman Omar A., A New Leukocyte Hyperadhesion Syndrome of Delayed Cord Separation, Skin Infection, and Nephrosis, Pediatrics, 133, 1, 2014. Crossref
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Qi Hai, Liu Bo, Run! White blood cells cued by a motor brain under stress, Cell Research, 2022. Crossref