Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Role of Innate Immunity in Transplantation Tolerance
RÉSUMÉ
Allogeneic organ transplantation has proven to be an effective therapeutic strategy for patients with end-stage organ disease. However, the chronic immunosuppression that is required for the survival of the allograft increases the risk for infection and malignancy. The establishment of transplantation tolerance, defined functionally as the survival of a donor allograft in the absence of immunosuppression, is the ultimate goal in the field of transplantation. Transplantation tolerance can be achieved using approaches that induce peripheral and/or central tolerance to the allograft. Protocols based on costimulation blockade (CB) have emerged as some of the most promising protocols for inducing long-term allograft survival in the absence of chronic immunosuppression. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation, which activate Toll-like receptors (TLR). In this review, we discuss how the activation of TLRs can affect the induction and maintenance of transplantation tolerance.
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Priyadharshini Bhavana, Thornley Thomas B., Daniels Keith A., Cuthbert Amy, Welsh Raymond M., Greiner Dale L., Brehm Michael A., Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death, Immunology, 138, 4, 2013. Crossref
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Priyadharshini Bhavana, Greiner Dale L., Brehm Michael A., T-cell activation and transplantation tolerance, Transplantation Reviews, 26, 3, 2012. Crossref
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Wang Hongjun, Wu Hongju, Rocuts Fredy, Gu Zhuoying, Bach Fritz H., Otterbein Leo E., Activation of Peroxisome Proliferator-Activated Receptor γ Prolongs Islet Allograft Survival, Cell Transplantation, 21, 10, 2012. Crossref
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Li Chao, Zhang Li-Min, Zhang Xue, Huang Xia, Liu Yong, Li Ming-Qiang, Xing Shuai, Yang Tao, Xie Lin, Jiang Feng-Chao, Jiang Han-Ying, He Wen-Tao, Zhou Ping, Short-term Pharmacological Inhibition of MyD88 Homodimerization by a Novel Inhibitor Promotes Robust Allograft Tolerance in Mouse Cardiac and Skin Transplantation, Transplantation, 101, 2, 2017. Crossref
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FrancoSalinas Gabriela, Mai Hoa-Le, Jovanovic Voja, Moizant Frédérique, Vanhove Bernard, Boeffard Francoise, Usal Claire, Tak Paul P., Soulillou Jean-Paul, Baeten Dominique, Brouard Sophie, TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model, Journal of Leukocyte Biology, 90, 2, 2011. Crossref