Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i2.30
27 pages

Transcriptional Regulation in B Cell Differentiation

David Liberg
Mikael Sigvardsson
Department of Cellular and Molecular Biology, Immunology Group, Lund University, Sweden


B cell development is a multistage differentiation process that ultimately generates antibody-secreting plasma cells. This model developmental pathway is governed by a choreographed pattern of expression from genes encoding stage and lineage-specific proteins. This is achieved by the interaction of distinct transcription factors with regulatory elements, placing these proteins in a central position in B cell ontogeny. The importance of distinct transcription factors is also supported by the notion that B cell development is disrupted in mice bearing homozygous null alleles of certain factors involved in the control of B-cell-specific genes. In this review we compare and contrast the transcriptional regulation of well-studied B lymphoid restricted genes, on a gene by gene basis, focusing on the functional structure of transcription control regions and interacting transcription factors.

Articles with similar content:

RUNX Expression and Function in Human B Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 1
Hannah J. Whiteman, Paul J. Farrell
Sp1 Control of Gene Expression in Myeloid Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 3
Karen K. Resendes, Alan G. Rosmarin
Developmental and Tissue-Specific Regulation of Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
David Goltzman, John H. White
Origin and Roles of Nuclear Matrix Proteins. Specific Functions of the MAR-Binding Protein MeCP2/ARBP
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Wolf H. Stratling, Fang Yu
Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 3
Brendan Boyce, Lianping Xing, Zhenqiang Yao