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Critical Reviews™ in Immunology
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ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i6.30
24 pages

Lymphocyte Calcium Signaling Involves Dihydropyridine-Sensitive L-Type Calcium Channels: Facts and Controversies

Bruno Gomes
INSERM U563, CHU Purpan, IFR 30, Place du Dr Baylac, 31024 Toulouse Cedex 3, France
Magali Savignac
INSERM U563, CHU Purpan, IFR 30, Place du Dr Baylac, 31024 Toulouse Cedex 3, France
Marc Moreau
CNRS Centre de Biologie du Developpement, UMR 5547; GDR CNRS 2688 Centre de Biologie du Developpement UMR 5547, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
Catherine Leclerc
CNRS Centre de Biologie du Developpement, UMR 5547; GDR CNRS 2688 Centre de Biologie du Developpement UMR 5547, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
Philippe Lory
CNRS UPR 2580 Laboratoire de Genomique Fonctionnelle, 141, rue de la cardonille 34094 Montpellier Cedex 05; GDR CNRS 2688 Centre de Biologie du Developpement UMR 5547, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
Jean-Charles Guery
INSERM U563, CHU Purpan, IFR 30, Place du Dr Baylac, 31024 Toulouse Cedex 3, France
Lucette Pelletier
INSERM U563, CHU Purpan, IFR 30, Place du Dr Baylac, 31024 Toulouse Cedex 3; GDR CNRS 2688 Centre de Biologie du Developpement UMR 5547, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 04, France

RÉSUMÉ

Calcium influx into lymphocytes is essential for activation, differentiation, and effector functions. While several channel- and receptor-types contribute to calcium influx, voltage-gated calcium channels (VGCC) mediate a well-characterized calcium influx pathway that is most exclusively identified in excitable cells. The role of L-type VGCCs, which belong to high-voltage activated calcium channels and are defined as dihydropyridine (DHP) receptors in excitable cells, is well documented. Interestingly, while lymphocytes do not range in the excitable cell category, the modulatory role of DHP agonists and antagonists and the identification of L-type VGCC-related molecules in B and T lymphocytes, mainly in Th2 cells, suggest these proteins are involved in the calcium response of these cells. Because the identity and the regulation of DHP receptors/channels in lymphocytes is far from being solved, we will discuss the challenging issues of demonstrating a role of L-type VGCCs in nonexcitable cells and the arguments supporting their role in lymphocytes. We will comment on the limitation of the use of DHP agonists and antagonists to ascertain a specific involvement of L-type VGCCs in lymphocyte calcium signaling. Finally, we will provide new clues on the interest of a potential use of DHP antagonists in Th2-cell-mediated pathology.


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