Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Tumor Antigen Presentation by Dendritic Cells
RÉSUMÉ
Tumor cells are generally regarded as poor stimulators of naive T cells. In contrast, dendritic cells (DCs) are highly specialized in this function, and are therefore likely to be important intermediaries in the process of stimulating T cell responses to tumors. While providing solid evidence that DCs participate in antitumor immunity has proved difficult, several lines of evidence point in this direction. First, animal models involving bone marrow chimeras have shown that cells of hematopoeitic origin are required to elicit T cell responses to whole-tumor vaccines. Second, compared with other cells of hematopoeitic origin, DCs are particularly well-equipped to cross-present exogenous antigens to CD8+ T cells, a critical function if intermediary cells are involved. Third, tumor-infiltrating DCs purified from tumor samples have the capacity to cross-present tumor antigens in vitro. Finally, priming of anti-tumor T cell responses can be abrogated in new in vivo models in which DCs can be specifically depleted. It is therefore significant that DCs in cancer patients are often kept in an immature or dysfunctional state, thereby preventing stimulation of tumor-specific T cells. This review describes the different steps required for DCs to elicit T cell responses to tumor-associated antigens, and highlights processes that are amenable to intervention as therapy. We conclude that effective anti-tumor activity may be dependent on the ability to re-program DCs resident in the host, perhaps even when transferred autologous DCs generated ex vivo are used as vaccines. In this context, recruiting the activity of cells of the innate immune system to condition host DCs may help elicit more effective T cell-mediated responses.
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Sick E, Jeanne A, Schneider C, Dedieu S, Takeda K, Martiny L, CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest, British Journal of Pharmacology, 167, 7, 2012. Crossref
-
Ochi Atsuo, Nguyen Andrew H., Bedrosian Andrea S., Mushlin Harry M., Zarbakhsh Saman, Barilla Rocky, Zambirinis Constantinos P., Fallon Nina C., Rehman Adeel, Pylayeva-Gupta Yuliya, Badar Sana, Hajdu Cristina H., Frey Alan B., Bar-Sagi Dafna, Miller George, MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells, Journal of Experimental Medicine, 209, 9, 2012. Crossref
-
Wen Chih-Chun, Chen Hui-Ming, Yang Ning-Sun, Developing Phytocompounds from Medicinal Plants as Immunomodulators, in Recent Trends in Medicinal Plants Research, 62, 2012. Crossref
-
Jarry Ulrich, Jeannin Pascale, Pineau Laurent, Donnou Sabrina, Delneste Yves, Couez Dominique, Efficiently stimulated adult microglia cross-prime naive CD8+T cells injected in the brain, European Journal of Immunology, 43, 5, 2013. Crossref
-
Cirone Mara, Garufi Alessia, Di Renzo Livia, Granato Marisa, Faggioni Alberto, D’Orazi Gabriella, Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells, OncoImmunology, 2, 9, 2013. Crossref
-
Rosalia Rodney A., Silva Ana Luisa, Camps Marcel, Allam Ahmed, Jiskoot Wim, van der Burg Sjoerd H., Ossendorp Ferry, Oostendorp Jaap, Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles, Cancer Immunology, Immunotherapy, 62, 7, 2013. Crossref
-
Zhang Zhuoli, Li Weiguo, Procissi Daniele, Li Kangan, Sheu Alexander Y., Gordon Andrew C., Guo Yang, Khazaie Khashayarsha, Huan Yi, Han Guohong, Larson Andrew C., Antigen-loaded Dendritic Cell Migration: MR Imaging in a Pancreatic Carcinoma Model, Radiology, 274, 1, 2015. Crossref
-
Dong Baijun, Minze Laurie J, Xue Wei, Chen Wenhao, Molecular insights into the development of T cell-based immunotherapy for prostate cancer, Expert Review of Clinical Immunology, 10, 11, 2014. Crossref
-
Aguilar-Cazares Dolores, Meneses-Flores Manuel, Prado-Garcia Heriberto, Islas-Vazquez Lorenzo, Rojo-Leon Veronica, Romero-Garcia Susana, Rivera-Rosales Rosa M., Lopez-Gonzalez Jose S., Relationship of Dendritic Cell Density, HMGB1 Expression, and Tumor-infiltrating Lymphocytes in Non–Small Cell Lung Carcinomas, Applied Immunohistochemistry & Molecular Morphology, 22, 2, 2014. Crossref
-
Kobukai Saho, Kremers Gert-Jan, Cobb Jared G., Baheza Richard, Xie Jingping, Kuley Alex, Zhu Meiying, Pham Wellington, Induction of Antitumor Immunity by Dendritic Cells Loaded with Membrane-Translocating Mucin 1 Peptide Antigen, Translational Oncology, 4, 1, 2011. Crossref
-
Ito Toshihiro, Carson William F., Cavassani Karen A., Connett Judith M., Kunkel Steven L., CCR6 as a mediator of immunity in the lung and gut, Experimental Cell Research, 317, 5, 2011. Crossref
-
Ponce Rafael A., Promises and Challenges with Immunomodulatory Biologics, in Molecular Immunotoxicology, 2014. Crossref
-
Gasparini Chiara, Tommasini Alberto, Zauli Giorgio, The MDM2 inhibitor Nutlin-3 modulates dendritic cell–induced T cell proliferation, Human Immunology, 73, 4, 2012. Crossref
-
Allen Clint T., Judd Nancy P., Bui Jack D., Uppaluri Ravindra, The clinical implications of antitumor immunity in head and neck cancer, The Laryngoscope, 122, 1, 2012. Crossref
-
Sampson John H., Mitchell Duane A., Vaccination strategies for neuro-oncology: Table 1., Neuro-Oncology, 17, suppl 7, 2015. Crossref
-
Chandrasekaran Siddarth, King Michael, Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy, International Journal of Molecular Sciences, 15, 11, 2014. Crossref
-
Cirone Mara, Di Renzo Livia, Lotti Lavinia Vittoria, Conte Valeria, Trivedi Pankaj, Santarelli Roberta, Gonnella Roberta, Frati Luigi, Faggioni Alberto, Busson Pierre, Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91, PLoS ONE, 7, 3, 2012. Crossref
-
Perche Federico, Torchilin Vladimir P., Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting, Journal of Drug Delivery, 2013, 2013. Crossref
-
Jara Evelyn L., Muñoz-Durango Natalia, Llanos Carolina, Fardella Carlos, González Pablo A., Bueno Susan M., Kalergis Alexis M., Riedel Claudia A., Modulating the function of the immune system by thyroid hormones and thyrotropin, Immunology Letters, 184, 2017. Crossref
-
Baroja-Mazo Alberto, Barberà-Cremades Maria, Pelegrín Pablo, Idzko Marco, P2X7 Receptor Activation Impairs Exogenous MHC Class I Oligopeptides Presentation in Antigen Presenting Cells, PLoS ONE, 8, 8, 2013. Crossref
-
Riccione K.A., Gedeon P., Sanchez-Perez L., Sampson J.H., Checkpoint Blockade Immunotherapy for Glioblastoma, in Translational Immunotherapy of Brain Tumors, 2017. Crossref
-
Strioga Marius, Schijns Virgil, Powell Daniel J, Pasukoniene Vita, Dobrovolskiene Neringa, Michalek Jaroslav, Dendritic cells and their role in tumor immunosurveillance, Innate Immunity, 19, 1, 2013. Crossref
-
Lybaert Lien, Vermaelen Karim, De Geest Bruno G., Nuhn Lutz, Immunoengineering through cancer vaccines – A personalized and multi-step vaccine approach towards precise cancer immunity, Journal of Controlled Release, 289, 2018. Crossref
-
Kroll Ashley V., Jiang Yao, Zhou Jiarong, Holay Maya, Fang Ronnie H., Zhang Liangfang, Biomimetic Nanoparticle Vaccines for Cancer Therapy, Advanced Biosystems, 3, 1, 2019. Crossref
-
Mirsoian Annie, Sckisel Gail D., Zamora Anthony E., Murphy William J., Impact of Obesity and Aging on the Tumor Immuno-Environment, in The Tumor Immunoenvironment, 2013. Crossref
-
Fleet J.C., Burcham G.N., Calvert R.D., Elzey B.D., Ratliff T.L., 1α, 25 Dihydroxyvitamin D (1,25(OH)2D) inhibits the T cell suppressive function of myeloid derived suppressor cells (MDSC), The Journal of Steroid Biochemistry and Molecular Biology, 198, 2020. Crossref
-
Ghosh Mallika, McAuliffe Beata, Subramani Jaganathan, Basu Sreyashi, Shapiro Linda H., CD13 Regulates Dendritic Cell Cross-Presentation and T Cell Responses by Inhibiting Receptor-Mediated Antigen Uptake, The Journal of Immunology, 188, 11, 2012. Crossref
-
Fotin-Mleczek Mariola, Zanzinger Kai, Heidenreich Regina, Lorenz Christina, Kowalczyk Aleksandra, Kallen Karl-Josef, Huber Stephan M, mRNA-based vaccines synergize with radiation therapy to eradicate established tumors, Radiation Oncology, 9, 1, 2014. Crossref
-
Zhang Bin, Dong Yuhao, Liu Jing, Lian Zhouyang, Liang Long, Chen Wenbo, Luo Xiaoning, Pei Shufang, Mo Xiaokai, Zhang Lu, Huang Wenhui, Ouyang Fusheng, Guo Baoliang, Liang Changhong, Zhang Shuixing, Immunotherapy for patients with advanced pancreatic carcinoma: a promising treatment, Oncotarget, 8, 4, 2017. Crossref
-
Gedeon Patrick C., Champion Cosette D., Rhodin Kristen E., Woroniecka Karolina, Kemeny Hanna R., Bramall Alexa N., Bernstock Joshua D., Choi Bryan D., Sampson John H., Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook, Expert Review of Clinical Pharmacology, 13, 10, 2020. Crossref
-
Cheng Chun-Chia, Lin Hsin-Chi, Chiang Ya-Wen, Chang Jungshan, Sie Zong-Lin, Yang Bi-Ling, Lim Ken-Hong, Peng Cheng-Liang, Ho Ai-Sheng, Chang Yi-Fang, Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression, Cancer Immunology, Immunotherapy, 70, 5, 2021. Crossref
-
Wang Ke, Chen Ruo, Feng Zhuan, Zhu Yu-Meng, Sun Xiu-Xuan, Huang Wan, Chen Zhi-Nan, Identification of differentially expressed genes in non-small cell lung cancer, Aging, 11, 23, 2019. Crossref
-
Wen Chih-Chun, Chen Hui-Ming, Chen Swey-Shen, Huang Li-Ting, Chang Wei-Ting, Wei Wen-Chi, Chou Li-Chen, Arulselvan Palanisamy, Wu Jin-Bin, Kuo Sheng-Chu, Yang Ning-Sun, Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines, Journal of Biomedical Science, 18, 1, 2011. Crossref
-
Shindo Yoshitaro, Hazama Shoichi, Maeda Yoshinari, Matsui Hiroto, Iida Michihisa, Suzuki Nobuaki, Yoshimura Kiyoshi, Ueno Tomio, Yoshino Shigefumi, Sakai Kohei, Suehiro Yutaka, Yamasaki Takahiro, Hinoda Yuji, Oka Masaaki, Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer, Journal of Translational Medicine, 12, 1, 2014. Crossref
-
Zhang Yu, Lin Shuibin, Wang Xiang‐Yang, Zhu Guizhi, Nanovaccines for cancer immunotherapy, WIREs Nanomedicine and Nanobiotechnology, 11, 5, 2019. Crossref
-
Hennies C M, Reboulet R A, Garcia Z, Nierkens S, Wolkers M C, Janssen E M, Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo , Clinical and Experimental Immunology, 163, 3, 2011. Crossref
-
Dang Yushe, Wagner Wolfgang M., Gad Ekram, Rastetter Lauren, Berger Carmen M., Holt Gregory E., Disis Mary L., Dendritic Cell–Activating Vaccine Adjuvants Differ in the Ability to Elicit Antitumor Immunity Due to an Adjuvant-Specific Induction of Immunosuppressive Cells, Clinical Cancer Research, 18, 11, 2012. Crossref
-
Keshavarz-Fathi Mahsa, Keshavarz-Fathi Mahdis, Rezaei Nima, Cancer Immunology, in Encyclopedia of Infection and Immunity, 2022. Crossref
-
Theobald Matthias, Brossart Peter, Seliger Barbara, Grundlagen der Tumorimmunologie, in Kompendium Internistische Onkologie, 2022. Crossref
-
Dolganiuc Angela, Szabo Gyongyi, Dendritic cells in hepatitis C infection: can they (help) win the battle?, Journal of Gastroenterology, 46, 4, 2011. Crossref
-
Younis Muhsin H., Tang Zhongmin, Cai Weibo, Multimodality imaging of nanoparticle‐based vaccines: Shedding light on immunology , WIREs Nanomedicine and Nanobiotechnology, 14, 5, 2022. Crossref