Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i1.20
pages 15-43

Scratching the Surface: Towards Understanding the Pathogenesis of Atopic Dermatitis

Sarita Sehra
Departments of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202
Florencia M. Barbe Tuana
Departments of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202
Mark Holbreich
Departments of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202
Nico Mousdicas
Departments of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202
Robert S. Tepper
Departments of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202
Cheong-Hee Chang
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109
Jeffrey B. Travers
Departments of Dermatology, and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202
Mark H. Kaplan
Departments of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202

RÉSUMÉ

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a steadily increasing prevalence affecting 10%−20% of infants and 1%−3% of adults globally. It is often the first clinical manifestation of atopic disease preceding asthma and allergic rhinitis. At least half of the children with AD develop some other form of atopic disease later in life. The pathogenesis of AD involves a complex interplay of factors, including genetic predisposition due to altered immune or skin barrier function, interactions with the environment, and infectious triggers of inflammation. In this review, we summarize the recent advances in understanding the contribution of different factors in the pathophysiology of AD in human and animal model systems. These insights provide new therapeutic potential for the treatment of human AD.


Articles with similar content:

CD4+ T Cell Activation During the Newborn Period: Barriers Against and Pathways Toward Th1 Immunity
Critical Reviews™ in Immunology, Vol.38, 2018, issue 1
Christina L. Lancioni, Luke S. Uebelhoer
MHC Genes Linked to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.35, 2015, issue 3
Philip Deitiker, M. Zouhair Atassi
CD40 Signaling to the Rescue: A CD8 Exhaustion Perspective in Chronic Infectious Diseases
Critical Reviews™ in Immunology, Vol.33, 2013, issue 4
Dustin A. Cobb, Imtiaz A. Khan, Rajarshi Bhadra
Sublesional Osteoporosis Prevention, Detection, and Treatment: A Decision Guide for Rehabilitation Clinicians Treating Patients with Spinal Cord Injury
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.20, 2008, issue 4
Beverley Craven, Lindsie Robertson, Lora Giangregorio, Janice J. Eng, Jude J. Delparte, Maureen C. Ashe
CD8 T Cells and Aging
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Rita B. Effros, Phyllis-Jean Linton, Zeling Cai