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Critical Reviews™ in Immunology
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ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i3.30
pages 215-227

Posttranslational Regulation of Cell-Surface Colony-Stimulating Factor-1

Keisuke Horiuchi
The Department of Anti-aging Orthopedic Research and The Department of Orthopedic Surgery, Keio University, School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
Yoshiaki Toyama
The Department of Orthopedic Surgery, Keio University, School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan


Colony-stimulating factor-1 (CSF-1) plays a central role in the survival, proliferation, differentiation, and function of monocytes and macrophages. CSF-1 is synthesized as both a soluble and a membrane-spanning growth factor. The membrane-spanning isoform is biologically active, but it can also be proteolytically cleaved to generate a soluble growth factor. A recent study revealed that the TNF-α-converting enzyme is involved in this activity, and, moreover, that membrane-spanning CSF-1 undergoes internalization. These findings may have important implications for the posttranslational regulation and the functions of cell-surface CSF-1.

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