Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.404 Facteur d'impact sur 5 ans: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v29.i5.20
pages 379-397

A Chimerism-Based Approach to Induce Tolerance in IgE-Mediated Allergy

Ulrike Baranyi
Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
Nina Pilat
Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
Martina Gattringer
Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
Thomas Wekerle
Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

RÉSUMÉ

Immunoglobulin-E-mediated allergy (type I allergy) is a T-helper-2-mediated disease with increasing prevalence in industrialized countries. Immunotherapy is available as causative treatment, but an effective preventive strategy is still an unmet need. Molecular chimerism is an attractive experimental approach that induces tolerance through transplantation of autologous hematopoietic stem cells that are genetically modified to express the disease-causing antigen(s). Molecular chimerism leads to permanent and robust tolerance in experimental models of autoimmune diseases and organ transplantation. Recently, proof-of-principle studies demonstrated that a type I allergic immune response can be durably tolerized by transplantation of allergen-expressing syngeneic bone marrow. We review the concept of tolerance induction through chimerism and discuss the potential of this strategy in immunoglobulin-E-mediated allergy.


Articles with similar content:

Mechanisms of Oral Tolerance
Critical Reviews™ in Immunology, Vol.17, 1997, issue 2
Paul Garside , Allan Mcl Mowat
The Role of Invariant NKT Cells in Allogeneic Hematopoietic Stem Cell Transplantation
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Aristeidis Chaidos, Anastasios Karadimitris
Defining Early Life Stress as a Precursor for Autoimmune Disease
Critical Reviews™ in Immunology, Vol.39, 2019, issue 5
Jamie Y. Choe, Maya Nair, Riyaz Basha, Harlan P. Jones, Byung-Jin Kim
Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6
Jon D. Laman, Randolph J. Noelle, Eric Claassen
Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Jon D. Laman, Randolph J. Noelle, Eric Claassen