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Critical Reviews™ in Immunology
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ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i1.50
pages 69-77

Prospects for the Development and Use of Gram-Negative Bacterial Virulence Protein Secretion Inhibitors for Prophylaxis and Treatment of Infectious Diseases

Heather B. Felise
Departments of Microbiology, University of Washington, Seattle, Washington, USA
Samuel I. Miller
Departments of Genome Science, Immunology, and Medicine, University of Washington, Seattle, Washington, USA

RÉSUMÉ

As the breadth and number of bacterial pathogens exhibiting antibiotic resistance is rapidly increasing, our ability to treat new and re-emerging infectious diseases is being threatened. Therefore, the development of new therapeutic strategies, including drugs acting on new targets, is required. In this review, the feasibility of gram-negative bacterial secretion systems for the development of anti-virulence agents and possible arenas for their utility in therapeutic intervention of gram-negative bacterial infections such as gastroenteritis, nosocomial infections, and venereal diseases are discussed.


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