Abonnement à la biblothèque: Guest
Critical Reviews™ in Immunology

Publication de 6  numéros par an

ISSN Imprimer: 1040-8401

ISSN En ligne: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Compartmentalization g/d T Cells and Their Putative Role in Mucosal Immunity

Volume 23, Numéro 5-6, 2003, 16 pages
DOI: 10.1615/CritRevImmunol.v23.i56.60
Get accessGet access

RÉSUMÉ

g/d T cells are an enigmatic group of cells and their functions still remain unknown. The epithelialassociated g/d T cells, which are abundant at mucosal surfaces, are ideally situated to contribute to the initial stages of the immune response. Recent evidence suggests that they recognize stress-induced self-antigens which would enable a homogenous population of g/d T cells to monitor multiple insults to the epithelium. This could explain the observed oligoclonality and homogenous distribution of cells carrying identical TCR within mucosal surfaces. However, the analysis of the TCR d repertoire from different mucosal surfaces indicated that g/d T cells are highly compartmentalized. Thus, g/d T cells are not one homogenous group of cells which recognize the same (stressinduced) self-antigens, but consist of different subsets that are likely to have distinct functions. It is possible that g/d T cells interact with antigens that are specific for that organ or recognize foreign antigens which are limited to that site. In addition it was shown that g/d T cells can have opposite functions and be proinflammatory or promote epithelial healing. This review focuses on the distribution and repertoire of mucosal g/d T cells and discusses what is currently known about the functions of these cells. Furthermore, their potential role in inflammatory bowel disease is examined.

CITÉ PAR
  1. Pietschmann K., Beetz S., Welte S., Martens I., Gruen J., Oberg H.-H., Wesch D., Kabelitz D., Toll-Like Receptor Expression and Function in Subsets of Human γδ T Lymphocytes, Scandinavian Journal of Immunology, 70, 3, 2009. Crossref

  2. Hayes Kelly S., Bancroft Allison J., Grencis Richard K., Immune-mediated regulation of chronic intestinal nematode infection, Immunological Reviews, 201, 1, 2004. Crossref

  3. Li Zhijie, Burns Alan R., Rumbaut Rolando E., Smith C. Wayne, γδ T Cells Are Necessary for Platelet and Neutrophil Accumulation in Limbal Vessels and Efficient Epithelial Repair after Corneal Abrasion, The American Journal of Pathology, 171, 3, 2007. Crossref

  4. Jimenez-Alvarez Luis, Zúñiga Joaquín, Gaxiola Miguel, Checa Marco, Becerril Carina, Mendoza Felipe, Pardo Annie, Selman Moisés, Inflammatory response and dynamics of lung T cell subsets in Th1, Th2 biased and Th2 deficient mice during the development of hypersensitivity pneumonitis, Experimental and Molecular Pathology, 88, 3, 2010. Crossref

  5. Gryglewski Andrzej, Majcher Pawel, Bryniarski Krzysztof, Konturek Stanislaw, Ptak Maria, Ptak Wlodzimierz, Szczepanik Marian, Mesenteric Lymph Node Tγδ Cells Induced by Gastrectomy in Mice Suppress Cell-Mediated Immune Response In Vitro via Released TGF-β, Journal of Surgical Research, 142, 1, 2007. Crossref

  6. Message Simon D., Johnston Sebastian L., Infections, in Asthma and COPD, 2009. Crossref

  7. Sahlmann Christian, Sutherland Ben J.G., Kortner Trond M., Koop Ben F., Krogdahl Åshild, Bakke Anne Marie, Early response of gene expression in the distal intestine of Atlantic salmon (Salmo salar L.) during the development of soybean meal induced enteritis, Fish & Shellfish Immunology, 34, 2, 2013. Crossref

  8. Kalyan Shirin, Kabelitz Dieter, Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic, Cellular & Molecular Immunology, 10, 1, 2013. Crossref

  9. Shekhar Sudhanshu, Milling Simon, Yang Xi, Migration of γδ T cells in steady-state conditions, Veterinary Immunology and Immunopathology, 147, 1-2, 2012. Crossref

  10. Kalyan Shirin, He Wei, Kabelitz Dieter, The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood γδ T cells for the treatment of bone cancer metastasis, in Bone Cancer, 2015. Crossref

  11. Do Jeongsu, Visperas Anabelle, Freeman Michael L., Jang Eunjung, Kim Sohee, Malissen Bernard, Min Booki, γδ T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b+ DCs in the mesenteric LN, European Journal of Immunology, 46, 2, 2016. Crossref

  12. Guzy Claudia, Paclik Daniela, Schirbel Anja, Sonnenborn Ulrich, Wiedenmann Bertram, Sturm Andreas, The probiotic Escherichia coli strain Nissle 1917 induces γδ T cell apoptosis via caspase- and FasL-dependent pathways, International Immunology, 20, 7, 2008. Crossref

  13. Tang Long, Kang Ning, He Wei, γδ T Cells in Immunoregulation, in Regulatory T Cells and Clinical Application, 2008. Crossref

  14. Dimova Tanya, Gamma/delta T cells in pregnancy, in Reproductive Immunology, 2021. Crossref

  15. Roden Anja C., Morice William G., Hanson Curtis A., Immunophenotypic Attributes of Benign Peripheral Blood γδ T Cells and Conditions Associated With Their Increase, Archives of Pathology & Laboratory Medicine, 132, 11, 2008. Crossref

  16. Pan Na, Liu Bohui, Bao Xuemei, Zhang Haochi, Sheng Shouxin, Liang Yanchen, Pan Haiting, Wang Xiao, Oral Delivery of Novel Recombinant Lactobacillus Elicit High Protection against Staphylococcus aureus Pulmonary and Skin Infections, Vaccines, 9, 9, 2021. Crossref

  17. Wang Sa A., T- and NK-Cell Lymphocytosis, in Diagnosis of Blood and Bone Marrow Disorders, 2018. Crossref

  18. Jiang Yan, Guo Yang, Xi Xueyan, Cui Lianxian, He Wei, Flanking V and J Sequences of Complementary Determining Region 3 of T Cell Receptor (TCR) δ1 (CDR3δ1) Determine the Structure and Function of TCRγ4δ1, Journal of Biological Chemistry, 286, 29, 2011. Crossref

  19. Beetz Susann, Marischen Lothar, Kabelitz Dieter, Wesch Daniela, Human γδ T cells, Immunologic Research, 37, 2, 2007. Crossref

  20. Champagne Eric, γδ T cell Receptor Ligands and Modes of Antigen Recognition, Archivum Immunologiae et Therapiae Experimentalis, 59, 2, 2011. Crossref

Prochains articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain