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Critical Reviews™ in Immunology

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ISSN Imprimer: 1040-8401

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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell−Based Immunotherapy

Volume 36, Numéro 6, 2016, pp. 445-460
DOI: 10.1615/CritRevImmunol.2017020166
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Alessandra Zingoni
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Elisabetta Vulpis
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Ilaria Nardone
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Alessandra Soriani
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Cinzia Fionda
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Marco Cippitelli
Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Italy
Angela Santoni
Laboratory of Immunology and Immunopathology, Department of Molecular Medicine and Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Universita di Roma, Rome, Italy

RÉSUMÉ

Natural killer (NK) cells are critical immune effector cells capable of mediating antitumor responses. These cytotoxic lymphocytes recognize transformed cells through a mechanism mainly dependent on the engagement of several activating receptors. However, many tumors have developed strategies to evade immunosurveillance and detection by NK cells. A relevant immune escape mechanism is the down regulation of NK cell activating ligands on the surface of tumor cells by proteolytic shedding mediated by different members of metalloproteinase families. Here, we consider two important NK activating receptors, namely NKG2D and NKp30, the ligands (i.e., MICA/B, ULBPs, and B7-H6) of which can be released by cancer cells through proteolytic cleavage. Modulation of ligand shedding in response to cancer therapy is also examined, and we discuss how metalloproteinases implicated in the ligand cleavage could be targeted in novel therapeutic schemes to counteract tumor escape from stress-elicited immune responses.

MOTS CLÉS: NK cells, immunotherapy, NKG2D, NKp30, shedding
CITÉ PAR

  1. Zingoni Alessandra, Fionda Cinzia, Borrelli Cristiana, Cippitelli Marco, Santoni Angela, Soriani Alessandra, Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance, Frontiers in Immunology, 8, 2017. Crossref

  2. Bruno Antonino, Bassani Barbara, D'Urso Davide Giuseppe, Pitaku Ilvana, Cassinotti Elisa, Pelosi Giuseppe, Boni Luigi, Dominioni Lorenzo, Noonan Douglas M., Mortara Lorenzo, Albini Adriana, Angiogenin and the MMP9‐TIMP2 axis are up‐regulated in proangiogenic, decidual NK‐like cells from patients with colorectal cancer, The FASEB Journal, 32, 10, 2018. Crossref

  3. Chiossone Laura, Dumas Pierre-Yves, Vienne Margaux, Vivier Eric, Natural killer cells and other innate lymphoid cells in cancer, Nature Reviews Immunology, 18, 11, 2018. Crossref

  4. Zingoni Alessandra, Molfetta Rosa, Fionda Cinzia, Soriani Alessandra, Paolini Rossella, Cippitelli Marco, Cerboni Cristina, Santoni Angela, NKG2D and Its Ligands: “One for All, All for One”, Frontiers in Immunology, 9, 2018. Crossref

  5. Zingoni Alessandra, Vulpis Elisabetta, Cecere Francesca, Amendola Maria G., Fuerst Daniel, Saribekyan Taron, Achour Adnane, Sandalova Tatyana, Nardone Ilaria, Peri Agnese, Soriani Alessandra, Fionda Cinzia, Mariggiò Elena, Petrucci Maria T., Ricciardi Maria R., Mytilineos Joannis, Cippitelli Marco, Cerboni Cristina, Santoni Angela, MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma, Frontiers in Immunology, 9, 2018. Crossref

  6. Riera-Domingo Carla, Audigé Annette, Granja Sara, Cheng Wan-Chen, Ho Ping-Chih, Baltazar Fátima, Stockmann Christian, Mazzone Massimiliano, Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy, Physiological Reviews, 100, 1, 2020. Crossref

  7. Hodgins Jonathan J., Khan Sarwat T., Park Maria M., Auer Rebecca C., Ardolino Michele, Killers 2.0: NK cell therapies at the forefront of cancer control, Journal of Clinical Investigation, 129, 9, 2019. Crossref

  8. Molfetta Rosa, Zingoni Alessandra, Santoni Angela, Paolini Rossella, Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention, Frontiers in Immunology, 10, 2019. Crossref

  9. Moloudizargari Milad, Abdollahi Mohammad, Asghari Mohammad Hossein, Zimta Alina Andreea, Neagoe Ioana Berindan, Nabavi Seyed Mohammad, The emerging role of exosomes in multiple myeloma, Blood Reviews, 38, 2019. Crossref

  10. Antonangeli Fabrizio, Zingoni Alessandra, Soriani Alessandra, Santoni Angela, Senescent cells: Living or dying is a matter of NK cells, Journal of Leukocyte Biology, 105, 6, 2019. Crossref

  11. Khan Muhammad, Arooj Sumbal, Wang Hua, NK Cell-Based Immune Checkpoint Inhibition, Frontiers in Immunology, 11, 2020. Crossref

  12. Frazao Alexandra, Rethacker Louise, Jeudy Géraldine, Colombo Marina, Pasmant Eric, Avril Marie-Françoise, Toubert Antoine, Moins-Teisserenc Helene, Roelens Marie, Dalac Sophie, Maubec Eve, Caignard Anne, BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis, Journal for ImmunoTherapy of Cancer, 8, 2, 2020. Crossref

  13. Yunus Muhammad Amir, Ramli Muhammad Mahyiddin, Osman Nurul Huda, Mohamed Rafeezul, Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression, Archivum Immunologiae et Therapiae Experimentalis, 69, 1, 2021. Crossref

  14. Hamilton Gerhard, Plangger Adelina, The Impact of NK Cell-Based Therapeutics for the Treatment of Lung Cancer for Biologics: Targets and Therapy, Biologics: Targets and Therapy, Volume 15, 2021. Crossref

  15. Tang Ying, Jiang Mei, Jiang Hai-Mei, Ye Zeng Jie, Huang Yu-Sheng, Li Xiu-Shen, Qin Bin-Yu, Zhou Rui-Sheng, Pan Hua-Feng, Zheng Da-Yong, The Roles of circRNAs in Liver Cancer Immunity, Frontiers in Oncology, 10, 2021. Crossref

  16. Li Zhaodong, Yu Bingxin, Qi Fangyuan, Li Fan, KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma, Frontiers in Oncology, 11, 2021. Crossref

  17. Fuertes Mercedes Beatriz, Domaica Carolina Inés, Zwirner Norberto Walter, Leveraging NKG2D Ligands in Immuno-Oncology, Frontiers in Immunology, 12, 2021. Crossref

  18. Balta Emre, Wabnitz Guido H., Samstag Yvonne, Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors, International Journal of Molecular Sciences, 22, 11, 2021. Crossref

  19. Abakushina Elena V., Popova Liubov I., Zamyatnin Andrey A., Werner Jens, Mikhailovsky Nikolay V., Bazhin Alexandr V., The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy, Vaccines, 9, 11, 2021. Crossref

  20. Vulpis Elisabetta, Loconte Luisa, Peri Agnese, Molfetta Rosa, Caracciolo Giulio, Masuelli Laura, Tomaipitinca Luana, Peruzzi Giovanna, Petillo Sara, Petrucci Maria Teresa, Fazio Francesca, Simonelli Lucilla, Fionda Cinzia, Soriani Alessandra, Cerboni Cristina, Cippitelli Marco, Paolini Rossella, Bernardini Giovanni, Palmieri Gabriella, Santoni Angela, Zingoni Alessandra, Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle‐associated MICA: Dual role in cancer immunosurveillance, Journal of Extracellular Vesicles, 11, 1, 2022. Crossref

  21. Biber Guy, Sabag Batel, Raiff Anat, Ben‐Shmuel Aviad, Puthenveetil Abhishek, Benichou Jennifer I C, Jubany Tammir, Levy Moria, Killner Shiran, Barda‐Saad Mira, Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity, EMBO Molecular Medicine, 14, 1, 2022. Crossref

  22. Kosta Andrea, Mekhloufi Abdelilah, Lucantonio Lorenzo, Zingoni Alessandra, Soriani Alessandra, Cippitelli Marco, Gismondi Angela, Fazio Francesca, Petrucci Maria Teresa, Santoni Angela, Stabile Helena, Fionda Cinzia, GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells, Frontiers in Immunology, 13, 2022. Crossref

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