Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
CD28-CD80/86 and CD40-CD40L Interactions Promote Thymic Tolerance by Regulating Medullary Epithelial Cell and Thymocyte Development
RÉSUMÉ
Development and central tolerance of T lymphocytes in the thymus requires both TCR signals and collaboration with signals generated through costimulatory molecule interactions. In this review, we discuss the importance of CD28-CD80/86 and CD40-CD40L costimulatory interactions in promoting normal thymic development. This discussion includes roles in the generation of a normal thymic medulla, in the development of specific T-cells subsets, including iNKT and T regulatory cells, and in the generation of a tolerant mature T-cell repertoire. We discuss recent contributions to the understanding of CD28-CD80/86 and CD40-CD40L costimulatory interactions in thymic development, and we highlight the ways in which the many important roles mediated by these interactions collaborate to promote normal thymic development.
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Poznyak Anastasia V., Bezsonov Evgeny E., Popkova Tatyana V., Starodubova Antonina V., Orekhov Alexander N., Immunity in Atherosclerosis: Focusing on T and B Cells, International Journal of Molecular Sciences, 22, 16, 2021. Crossref
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Friedman David J., Kizerwetter Monika, Belmonte Paul, Rajcula Matthew, Theodore Keith, Kim Lee Hyun Se, Shapiro Michael J., Dong Haidong, Shapiro Virginia Smith, Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice, The Journal of Immunology, 208, 8, 2022. Crossref
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Martinez‐Ruíz Gustavo Ulises, Morales‐Sánchez Abigail, Bhandoola Avinash, Transcriptional and epigenetic regulation in thymic epithelial cells*, Immunological Reviews, 305, 1, 2022. Crossref
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Díaz Álvaro, González-Alayón Ignacio, Pérez-Torrado Valentina, Suárez-Martins Mariana, CD40-CD154: A perspective from type 2 immunity, Seminars in Immunology, 53, 2021. Crossref