Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v19.i4.10
24 pages

Immunopotentiating and Immunotherapeutic Effects of Thymic Hormones and Factors with Special Emphasis on Thymic Humoral Factor THF-γ2

Shlomo Ben-Efraim
Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Yigal Burstein
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
Yona Keisari
Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Rachel Ophir
Department of Human Microbiology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Marit Pecht
Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
Nathan Trainin
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel

RÉSUMÉ

The essential role played by the thymus in the development of the immune response was well documented in many publications. These findings prompted a long series of studies devised to define the factors produced and secreted by thymus cells, which are involved in the development and nature of immunological responsiveness. First experiments done with crude thymus extracts were followed by isolation of purified products and finally by chemical characterization and synthesis of immunologically active thymus-derived peptides.
In this article we review the various thymic hormones and factors described, that is, thymosin fractions 5, the thymosins, prothymosin α, thymulin (FTS-Zn), thymopoietin, thymostimulin (TP-1), Thymic humoral factor (THF), and THF-γ2. Studies demonstrating the activity of the various thymic factors in increasing the immuno-competence potential in both in vitro and in vivo conditions are discussed. The immunostimulatory potential of thymic factors was also investigated in experimental models where beneficial therapeutic effects were sought in a situation of immunological malfunction. The last part of the review is dedicated to clinical trials with thymic factors that revealed improvement in the immunocompetence potential in cases of immunodeficiencies, viral infections, and cancer and its correlation with therapeutic effectiveness. It seems that more research is required in order to better define conditions for the use of thymic factors in immunotherapy.


Articles with similar content:

Expression and Function of Fc Receptors in the Thymus
Critical Reviews™ in Immunology, Vol.15, 1995, issue 3-4
Georges Leclercq , Jean Plum
Optimization of Immunotherapy in Elderly Cancer Patients
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 6
Kei Tomihara, Tyler J. Curiel, Bin Zhang
Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 1
Yue Guo, Gaurav Gupta, Huanyu Lu, Xingsong Tian
MEASUREMENT OF EXTENSIONAL VISCOSITY OF POLYMER SOLUTIONS AND ITS EFFECTS ON ATOMIZATION FROM A SPRAY NOZZLE
Atomization and Sprays, Vol.6, 1996, issue 2
R. W. Dexter
Immunological Effects of Thalidomide and Its Chemical and Functional Analogs
Critical Reviews™ in Immunology, Vol.22, 2002, issue 5-6
J. Blake Marriott, Keith Dredge, Angus G. Dalgleish