Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i3.40
pages 233-245

Rapid Clearance of Bacteria and Their Toxins: Development of Therapeutic Proteins

Meghan Kunkel
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Momchilo Vuyisich
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Gnana Gnanakaran
Theory Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
George E. Bruening
Plant Pathology, UC Davis, Davis, CA 95616, USA
Abhaya M. Dandekar
Plant Sciences, UC Davis, Davis, CA 95616, USA
Edwin Civerolo
San Joaquin Valley Agricultural Sciences Center, USDA-ARS, Parlier, Parlier, CA 93648, USA
John J. Marchalonis
Department of Immunobiology, University of Arizona College of Medicine P.O. Box 24-5049 Tucson, AZ 85724
Goutam Gupta
Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA


The emergence of pathogens and toxins with resistance against conventional drugs, vaccines, and host defense peptides and proteins warrants novel countermeasures that can efficiently capture and rapidly clear them. This article examines the utility of chimeric proteins with capture and clearance domains as a novel countermeasure against pathogens and their toxins. The capture and clearance domains are chosen from the large repertoire of host defense peptides and proteins. Although individual capture and clearance domains are rendered ineffective by pathogenic resistance mechanisms, chimeric scaffolds can be designed to retain their antimicrobial activity, even in the face of pathogenic resistance. Here, initial studies on the design of chimeric proteins targeted against (1) intact bacteria such as Xylella fastidiosa (plant pathogens), Salmonella spp. (food-borne pathogens), and Staphylococcus aureus (blood-borne pathogens); and (2) lethal toxins from Bacillus anthracis are described.

Articles with similar content:

Staphylococcal Superantigen Super-Domains in Immune Evasion
Critical Reviews™ in Immunology, Vol.30, 2010, issue 2
John D. Fraser, Fiona Clow, Ries Langley, Nicola Jackson, Deepa Patel
Insights into the Distribution and Functions of the Eukaryotic GPI-like Anchored Genes Among Mycobacterium from a Comparative Genomic Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 4
Jianping Xie, Jie Zeng, Wanyan Deng, Xiaohong Xiang
The Human Immune System against Staphylococcus epidermidis
Critical Reviews™ in Immunology, Vol.39, 2019, issue 3
Mirzaei Rasoul, Mohammadzadeh Rokhsareh, Shokri Moghadam Mohammad, Moradi Ahmadreza, Karampoor Sajad
Molecular Interactions Between Dendritic Cells and Salmonella: Escape from Adaptive Immunity and Implications on Pathogenesis
Critical Reviews™ in Immunology, Vol.25, 2005, issue 5
Mirentxu I. Iruretagoyena, Alexis M. Kalergis, Jaime A. Tobar, Susan M. Bueno
The Phenotype and Function of Lung Dendritic Cells
Critical Reviews™ in Immunology, Vol.25, 2005, issue 6
Allison T. Thiele, Kena A. Swanson, Tina L. Sumpter, Tonya J. Webb, David S. Wilkes