Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.404 Facteur d'impact sur 5 ans: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017019636
pages 1-13

The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells

Adriana Alicia Cabrera-Ortega
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil
Daniel Feinberg
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
Youde Liang
Department of Stomatology, Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, Guangdong, China
Carlos Rossa, Jr.
Department of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil
Dana T. Graves
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

RÉSUMÉ

Forkhead box-O (FOXO) transcription factors have a fundamental role in the development and differentiation of immune cells. FOXO1 and FOXO3 are FOXO members that are structurally similar and bind to the same conserved consensus DNA sequences to induce transcription. FOXO1 has been studied in detail in the activation of dendritic cells (DCs), where it plays an important role through the regulation of target genes such as ICAM-1, CCR7, and the integrin αvβ3. FOXO1 is activated by bacteria challenge in DCs and promotes DC bacterial phagocytosis, migration, homing to lymph nodes, DC stimulation of CD4+ T cells and resting B cells, and antibody production. Deletion of FOXO1 in DCs enhances susceptibility to bacteria-induced periodontal disease. FOXO1 and FOXO3 maintain naive T cell quiescence and survival. FOXO1 and FOXO3 enhance the formation of regulatory T cells and inhibit the formation of T-helper 1 (Th1) and Th17 cells. FOXO1 promotes differentiation, proliferation, survival, immunoglobulin gene rearrangement, and class switching in B cells, but FOXO3 has little effect. Both FOXO1 and FOXO3 are important in the maintenance of hematopoietic stem cells by protecting them from oxidative stress. This review examines FOXO1/FOXO3 in the adaptive immune response, key target genes, and FOXO inhibition by the phosphoinositide 3-kinase/AKT pathway.


Articles with similar content:

Role of Diacylglycerol Kinases in T Cell Development and Function
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Sruti Krishna , Xiaoping Zhong
Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Jon D. Laman, Randolph J. Noelle, Eric Claassen
Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6
Jon D. Laman, Randolph J. Noelle, Eric Claassen
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells
Critical Reviews™ in Immunology, Vol.38, 2018, issue 5
Jessica Bourque, Daniel Hawiger
Function of Neurotrophic Factors Beyond the Nervous System: Inflammation and Autoimmune Demyelination
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Ralf Linker, Ralf Gold, Fred Luhder